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An unusual presentation of neonatal rhabdomyosarcoma: a case report

A full-term infant with an unremarkable prenatal course presented at birth with a large midline facial mass and smaller masses in the head and neck. In addition, multiple diffuse flesh-colored nodules spread along all the upper and lower limbs. An extensive evaluation to cover a broad differential d...

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Autores principales: Strah, Danielle, Stanley, Kelly, Oatmen, Kelsie, Kylat, Ranjit I., Dishop, Megan, de la Maza, Michelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641497/
https://www.ncbi.nlm.nih.gov/pubmed/37964815
http://dx.doi.org/10.3389/fped.2023.1233334
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author Strah, Danielle
Stanley, Kelly
Oatmen, Kelsie
Kylat, Ranjit I.
Dishop, Megan
de la Maza, Michelina
author_facet Strah, Danielle
Stanley, Kelly
Oatmen, Kelsie
Kylat, Ranjit I.
Dishop, Megan
de la Maza, Michelina
author_sort Strah, Danielle
collection PubMed
description A full-term infant with an unremarkable prenatal course presented at birth with a large midline facial mass and smaller masses in the head and neck. In addition, multiple diffuse flesh-colored nodules spread along all the upper and lower limbs. An extensive evaluation to cover a broad differential diagnosis of infectious, lymphatic/vascular, and oncologic etiology was undertaken. The initial suspicion was confirmed by biopsy of the skin lesion as congenital alveolar rhabdomyosarcoma (RMS). RMS is the most common soft tissue sarcoma that occurs in childhood. However, neonatal RMS is exceedingly rare. The infant’s initial treatment included vincristine, dactinomycin, and cyclophosphamide in addition to salvage ifosfamide and etoposide, which were dose-adjusted for age. Herein, we present a case of an infant with RMS who showed initial improvement before relapsing and succumbing to her disease at 5 months of age. A review of the limited literature available on this rare condition and newer treatment regimens with improved mortality rates is performed.
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spelling pubmed-106414972023-11-14 An unusual presentation of neonatal rhabdomyosarcoma: a case report Strah, Danielle Stanley, Kelly Oatmen, Kelsie Kylat, Ranjit I. Dishop, Megan de la Maza, Michelina Front Pediatr Pediatrics A full-term infant with an unremarkable prenatal course presented at birth with a large midline facial mass and smaller masses in the head and neck. In addition, multiple diffuse flesh-colored nodules spread along all the upper and lower limbs. An extensive evaluation to cover a broad differential diagnosis of infectious, lymphatic/vascular, and oncologic etiology was undertaken. The initial suspicion was confirmed by biopsy of the skin lesion as congenital alveolar rhabdomyosarcoma (RMS). RMS is the most common soft tissue sarcoma that occurs in childhood. However, neonatal RMS is exceedingly rare. The infant’s initial treatment included vincristine, dactinomycin, and cyclophosphamide in addition to salvage ifosfamide and etoposide, which were dose-adjusted for age. Herein, we present a case of an infant with RMS who showed initial improvement before relapsing and succumbing to her disease at 5 months of age. A review of the limited literature available on this rare condition and newer treatment regimens with improved mortality rates is performed. Frontiers Media S.A. 2023-10-27 /pmc/articles/PMC10641497/ /pubmed/37964815 http://dx.doi.org/10.3389/fped.2023.1233334 Text en © 2023 Strah, Stanley, Oatmen, Kylat, Dishop and de la Maza. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Strah, Danielle
Stanley, Kelly
Oatmen, Kelsie
Kylat, Ranjit I.
Dishop, Megan
de la Maza, Michelina
An unusual presentation of neonatal rhabdomyosarcoma: a case report
title An unusual presentation of neonatal rhabdomyosarcoma: a case report
title_full An unusual presentation of neonatal rhabdomyosarcoma: a case report
title_fullStr An unusual presentation of neonatal rhabdomyosarcoma: a case report
title_full_unstemmed An unusual presentation of neonatal rhabdomyosarcoma: a case report
title_short An unusual presentation of neonatal rhabdomyosarcoma: a case report
title_sort unusual presentation of neonatal rhabdomyosarcoma: a case report
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641497/
https://www.ncbi.nlm.nih.gov/pubmed/37964815
http://dx.doi.org/10.3389/fped.2023.1233334
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