“Affimer” synthetic protein scaffolds block oxidized LDL binding to the LOX-1 scavenger receptor and inhibit ERK1/2 activation

In multicellular organisms, a variety of lipid-protein particles control the systemic flow of triacylglycerides, cholesterol, and fatty acids between cells in different tissues. The chemical modification by oxidation of these particles can trigger pathological responses, mediated by a group of membr...

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Detalles Bibliográficos
Autores principales: Roper, Barnaby W.R., Tiede, Christian, Abdul-Zani, Izma, Cuthbert, Gary A., Jade, Dhananjay, Al-Aufi, Ahmed, Critchley, William R., Saikia, Queen, Homer-Vanniasinkam, Shervanthi, Sawamura, Tatsuya, McPherson, Michael J., Harrison, Michael A., Tomlinson, Darren C., Ponnambalam, Sreenivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641530/
https://www.ncbi.nlm.nih.gov/pubmed/37805141
http://dx.doi.org/10.1016/j.jbc.2023.105325

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