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Cell cycle responses to Topoisomerase II inhibition: Molecular mechanisms and clinical implications

DNA Topoisomerase IIA (Topo IIA) is an enzyme that alters the topological state of DNA and is essential for the separation of replicated sister chromatids and the integrity of cell division. Topo IIA dysfunction activates cell cycle checkpoints, resulting in arrest in either the G2-phase or metaphas...

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Detalles Bibliográficos
Autores principales:	Soliman, Tanya N., Keifenheim, Daniel, Parker, Peter J., Clarke, Duncan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641588/ https://www.ncbi.nlm.nih.gov/pubmed/37955972 http://dx.doi.org/10.1083/jcb.202209125

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