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Arg177 and Asp159 from dog prion protein slow liquid–liquid phase separation and inhibit amyloid formation of human prion protein

Prion diseases are a group of transmissible neurodegenerative diseases primarily caused by the conformational conversion of prion protein (PrP) from α-helix-dominant cellular prion protein (PrP(C)) to β-sheet-rich pathological aggregated form of PrP(Sc) in many mammalian species. Dogs exhibit resist...

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Detalles Bibliográficos
Autores principales:	Li, Xiang-Ning, Gao, Yuan, Li, Yang, Yin, Jin-Xu, Yi, Chuan-Wei, Yuan, Han-Ye, Huang, Jun-Jie, Wang, Li-Qiang, Chen, Jie, Liang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641668/ https://www.ncbi.nlm.nih.gov/pubmed/37805139 http://dx.doi.org/10.1016/j.jbc.2023.105329

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