Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production

OBJECTIVE: FAS-mediated apoptosis of hepatocytes and aberrant TGF-β signaling are major drivers of liver fibrosis. Decreased miRNA let-7 expression in the livers of patients and animals with fibrosis suggests a mechanistic link of let-7 to hepatic fibrogenesis. METHODS: Using transient transfection...

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Detalles Bibliográficos
Autores principales: Song, Jiahui, Lv, Haining, Liu, Beibei, Hao, Mingjun, Taylor, Hugh S., Zhang, Xuchen, Li, Da, Huang, Yingqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641683/
https://www.ncbi.nlm.nih.gov/pubmed/37898449
http://dx.doi.org/10.1016/j.molmet.2023.101828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641683/
https://www.ncbi.nlm.nih.gov/pubmed/37898449
http://dx.doi.org/10.1016/j.molmet.2023.101828

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