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Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production

OBJECTIVE: FAS-mediated apoptosis of hepatocytes and aberrant TGF-β signaling are major drivers of liver fibrosis. Decreased miRNA let-7 expression in the livers of patients and animals with fibrosis suggests a mechanistic link of let-7 to hepatic fibrogenesis. METHODS: Using transient transfection...

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Detalles Bibliográficos
Autores principales:	Song, Jiahui, Lv, Haining, Liu, Beibei, Hao, Mingjun, Taylor, Hugh S., Zhang, Xuchen, Li, Da, Huang, Yingqun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641683/ https://www.ncbi.nlm.nih.gov/pubmed/37898449 http://dx.doi.org/10.1016/j.molmet.2023.101828

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