Cargando…

Noninvasive diagnosis of secondary infections in COVID-19 by sequencing of plasma microbial cell-free DNA

Secondary infection (SI) diagnosis in severe COVID-19 remains challenging. We correlated metagenomic sequencing of plasma microbial cell-free DNA (mcfDNA-Seq) with clinical SI assessment, immune response, and outcomes. We classified 42 COVID-19 inpatients as microbiologically confirmed-SI (Micro-SI,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lisius, Grace, Duttagupta, Radha, Ahmed, Asim A., Hensley, Matthew, Al-Yousif, Nameer, Lu, Michael, Bain, William, Shah, Faraaz, Blauwkamp, Timothy A., Bercovici, Sivan, Schaefer, Caitlin, Qin, Shulin, Wang, Xiaohong, Zhang, Yingze, Mitchell, Kevin J., Hughes, Ellen K., Jacobs, Jana L., Naqvi, Asma, Haidar, Ghady, Mellors, John W., Methé, Barbara, McVerry, Bryan J., Morris, Alison, Kitsios, Georgios D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641743/ https://www.ncbi.nlm.nih.gov/pubmed/37965142 http://dx.doi.org/10.1016/j.isci.2023.108093

Ejemplares similares

Plasma microbial cell-free DNA load is associated with mortality in patients with COVID-19
por: Kitsios, Georgios D., et al.
Publicado: (2021)

Metagenomic identification of severe pneumonia pathogens in mechanically-ventilated patients: a feasibility and clinical validity study
por: Yang, Libing, et al.
Publicado: (2019)

Plasma SARS-CoV-2 RNA levels as a biomarker of lower respiratory tract SARS-CoV-2 infection in critically ill patients with COVID-19
por: Jacobs, Jana L., et al.
Publicado: (2022)

The upper and lower respiratory tract microbiome in severe aspiration pneumonia
por: Kitsios, Georgios D., et al.
Publicado: (2023)

Biomarker-Based Classification of Patients With Acute Respiratory Failure Into Inflammatory Subphenotypes: A Single-Center Exploratory Study
por: Drohan, Callie M., et al.
Publicado: (2021)

A Pilot Double-Blind Placebo-Controlled Randomized Clinical Trial to Investigate the Effects of Early Enteral Nutrients in Sepsis
por: Shah, Faraaz Ali, et al.
Publicado: (2021)

Trajectories of host-response biomarkers and inflammatory subphenotypes in COVID-19 patients across the spectrum of respiratory support
por: Lu, Michael, et al.
Publicado: (2022)

Distinct profiles of host responses between plasma and lower respiratory tract during acute respiratory failure
por: Kitsios, Georgios D., et al.
Publicado: (2023)

Respiratory Fungal Communities are Associated with Systemic Inflammation and Predict Survival in Patients with Acute Respiratory Failure
por: Britton, Noel, et al.
Publicado: (2023)

COVID-19 versus Non–COVID-19 Acute Respiratory Distress Syndrome: Comparison of Demographics, Physiologic Parameters, Inflammatory Biomarkers, and Clinical Outcomes
por: Bain, William, et al.
Publicado: (2021)

245. Plasma and Respiratory Specimen Metagenomic Sequencing for the Diagnosis of Severe Pneumonia in Mechanically-Ventilated Patients
por: Kitsios, Georgios, et al.
Publicado: (2019)

Respiratory Microbiome Profiling for Etiologic Diagnosis of Pneumonia in Mechanically Ventilated Patients
por: Kitsios, Georgios D., et al.
Publicado: (2018)

Plasma 1,3-β-d-glucan levels predict adverse clinical outcomes in critical illness
por: Kitsios, Georgios D., et al.
Publicado: (2021)

Rectal Swabs from Critically Ill Patients Provide Discordant Representations of the Gut Microbiome Compared to Stool Samples
por: Fair, Katherine, et al.
Publicado: (2019)

Prognostic Insights from Longitudinal Multicompartment Study of Host-Microbiota Interactions in Critically Ill Patients
por: Kitsios, Georgios D., et al.
Publicado: (2023)

Prognostic Insights from Longitudinal Multicompartment Study of Host-Microbiota Interactions in Critically Ill Patients
por: Kitsios, Georgios D., et al.
Publicado: (2023)

Association of the systemic host immune response with acute hyperglycemia in mechanically ventilated septic patients
por: Farooq, Nauman, et al.
Publicado: (2021)

Serum metabolomic signatures of fatty acid oxidation defects differentiate host-response subphenotypes of acute respiratory distress syndrome
por: Suber, Tomeka L., et al.
Publicado: (2023)

Contribution of Coronavirus-Specific Immunoglobulin G Responses to Complement Overactivation in Patients with Severe Coronavirus Disease 2019( )
por: Castanha, Priscila M S, et al.
Publicado: (2022)

No evidence of hemoglobin damage by SARS-CoV-2 infection
por: DeMartino, Anthony W., et al.
Publicado: (2020)

Improving the Outcomes of Immunocompromised Patients With Coronavirus Disease 2019
por: Haidar, Ghady, et al.
Publicado: (2021)

Physiologic Effects of Exogenous Dextrose in Murine Klebsiella pneumoniae Sepsis Vary by Route of Provision
por: Chuan, Byron, et al.
Publicado: (2020)

Budget Impact of Microbial Cell-Free DNA Testing Using the Karius(®) Test as an Alternative to Invasive Procedures in Immunocompromised Patients with Suspected Invasive Fungal Infections
por: MacIntyre, Ann T., et al.
Publicado: (2020)

Magnetic-activated cell sorting identifies a unique lung microbiome community
por: Dunlap, Daniel G., et al.
Publicado: (2023)

Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia
por: Lai, Yandong, et al.
Publicado: (2021)

Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis
por: Lai, Yandong, et al.
Publicado: (2023)

Suppressed renoprotective purines in COVID-19 patients with acute kidney injury
por: Jackson, Edwin K., et al.
Publicado: (2022)

Inter-rater reliability and prognostic value of baseline Radiographic Assessment of Lung Edema (RALE) scores in observational cohort studies of inpatients with COVID-19
por: Al-Yousif, Nameer, et al.
Publicado: (2023)

983. Use of plasma-based microbial cell-free DNA (mcfDNA) sequencing for surveillance of infection in the 1st month after lung transplant (LT): a prospective, observational, pilot study
por: Haidar, Ghady, et al.
Publicado: (2023)

A common single nucleotide polymorphism is associated with inflammation and critical illness outcomes
por: El-Dehaibi, Fayten, et al.
Publicado: (2023)

Factor H preserves alternative complement function during ARDS, linked to improved survival
por: Bain, William, et al.
Publicado: (2023)

Lower Respiratory Tract Myeloid Cells Harbor SARS-Cov-2 and Display an Inflammatory Phenotype
por: Bain, William G., et al.
Publicado: (2021)

810. Diagnosis of BCG Aortitis by Plasma Metagenomic Sequencing
por: Cooper, Chris, et al.
Publicado: (2018)

Improved Detection of Culprit Pathogens by Bacterial DNA Sequencing Affects Antibiotic Management Decisions in Severe Pneumonia
por: Dunlap, Daniel G., et al.
Publicado: (2018)

Nocturnal Hypoxia Improves Glucose Disposal, Decreases Mitochondrial Efficiency, and Increases Reactive Oxygen Species in the Muscle and Liver of C57BL/6J Mice Independent of Weight Change
por: Ioja, Simona, et al.
Publicado: (2018)

Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19
por: Peddireddy, Sai Preetham, et al.
Publicado: (2022)

Coronavirus Disease 2019 (COVID-19), Organ Transplantation, and the Nuances of Immunomodulation: Lessons Learned and What Comes Next
por: Haidar, Ghady
Publicado: (2020)

Immunity to a third BNT162B2 COVID-19 vaccine after heart transplantation: Bridging the knowledge gap to end the pandemic for organ transplant recipients
por: Haidar, Ghady
Publicado: (2022)

Cryptococcus: Shedding New Light on an Inveterate Yeast
por: Haidar, Ghady, et al.
Publicado: (2015)

870. Plasma microbial cell-free DNA sequencing impacts antimicrobial management in immunocompromised patients with pneumonia
por: Madut, Deng B, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5t2kboqgg6hi2ldi7j6n60ha58