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TMEM106B reduction does not rescue GRN deficiency in iPSC-derived human microglia and mouse models

Heterozygous mutations in the granulin (GRN) gene are a leading cause of frontotemporal lobar degeneration with TDP-43 aggregates (FTLD-TDP). Polymorphisms in TMEM106B have been associated with disease risk in GRN mutation carriers and protective TMEM106B variants associated with reduced levels of T...

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Detalles Bibliográficos
Autores principales:	Dominguez, Sara L., Laufer, Benjamin I., Ghosh, Arundhati Sengupta, Li, Qingling, Ruggeri, Gaia, Emani, Maheswara Reddy, Phu, Lilian, Friedman, Brad A., Sandoval, Wendy, Rose, Christopher M., Ngu, Hai, Foreman, Oded, Reichelt, Mike, Juste, Yves, Lalehzadeh, Guita, Hansen, Dennis, Nymark, Helle, Mellal, Denia, Gylling, Helene, Kiełpiński, Łukasz J., Chih, Ben, Bingol, Baris, Hoogenraad, Casper C., Meilandt, William J., Easton, Amy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641752/ https://www.ncbi.nlm.nih.gov/pubmed/37965143 http://dx.doi.org/10.1016/j.isci.2023.108362

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