4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells

[Image: see text] We synthesized new pyrrole and indole derivatives as human carbonic anhydrase (hCA) inhibitors with the potential to inhibit the Wnt/β-catenin signaling pathway. The presence of both N1-(4-sulfonamidophenyl) and 3-(3,4,5-trimethoxyphenyl) substituents was essential for strong hCA i...

Descripción completa

Detalles Bibliográficos
Autores principales: Masci, Domiziana, Puxeddu, Michela, Di Magno, Laura, D’Ambrosio, Michele, Parisi, Anastasia, Nalli, Marianna, Bai, Ruoli, Coluccia, Antonio, Sciò, Pietro, Orlando, Viviana, D’Angelo, Sara, Biagioni, Stefano, Urbani, Andrea, Hamel, Ernest, Nocentini, Alessio, Filiberti, Serena, Turati, Marta, Ronca, Roberto, Kopecka, Joanna, Riganti, Chiara, Fionda, Cinzia, Bordone, Rosa, Della Rocca, Giorgia, Canettieri, Gianluca, Supuran, Claudiu T., Silvestri, Romano, La Regina, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641813/
https://www.ncbi.nlm.nih.gov/pubmed/37902628
http://dx.doi.org/10.1021/acs.jmedchem.3c01424

Ejemplares similares

Ejemplares similares