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Exploring the role of gut microbiota in autoimmune thyroid disorders: a systematic review and meta-analysis

BACKGROUND: Autoimmune thyroid diseases (AITDs) are characterized by unique immune responses against thyroid antigens and persist over time. The most common types of AITDs are Graves' disease (GD) and Hashimoto's thyroiditis (HT). There is mounting evidence that changes in the micr...

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Autores principales: Alkader, Dania Akeil Abed, Asadi, Naweedullah, Solangi, Uzma, Singh, Ransherjit, Rasuli, Sayed Farhad, Farooq, Muhammad Jawad, Raheela, F. N. U., Waseem, Radeyah, Gilani, Syed Mujahid, Abbas, Kiran, Ahmed, Moiz, Tanoh, Desmond Boakye, Shah, Hussain Haider, Dulal, Ayusha, Hussain, Muhammad Sheheryar, Talpur, Abdul Subhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641821/
https://www.ncbi.nlm.nih.gov/pubmed/37964972
http://dx.doi.org/10.3389/fendo.2023.1238146
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author Alkader, Dania Akeil Abed
Asadi, Naweedullah
Solangi, Uzma
Singh, Ransherjit
Rasuli, Sayed Farhad
Farooq, Muhammad Jawad
Raheela, F. N. U.
Waseem, Radeyah
Gilani, Syed Mujahid
Abbas, Kiran
Ahmed, Moiz
Tanoh, Desmond Boakye
Shah, Hussain Haider
Dulal, Ayusha
Hussain, Muhammad Sheheryar
Talpur, Abdul Subhan
author_facet Alkader, Dania Akeil Abed
Asadi, Naweedullah
Solangi, Uzma
Singh, Ransherjit
Rasuli, Sayed Farhad
Farooq, Muhammad Jawad
Raheela, F. N. U.
Waseem, Radeyah
Gilani, Syed Mujahid
Abbas, Kiran
Ahmed, Moiz
Tanoh, Desmond Boakye
Shah, Hussain Haider
Dulal, Ayusha
Hussain, Muhammad Sheheryar
Talpur, Abdul Subhan
author_sort Alkader, Dania Akeil Abed
collection PubMed
description BACKGROUND: Autoimmune thyroid diseases (AITDs) are characterized by unique immune responses against thyroid antigens and persist over time. The most common types of AITDs are Graves' disease (GD) and Hashimoto's thyroiditis (HT). There is mounting evidence that changes in the microbiota may play a role in the onset and development of AITDs. OBJECTIVE: The purpose of this comprehensive literature study was to answer the following query: Is there a difference in microbiota in those who have AITDs? METHODS: According to the standards set out by the PRISMA statement, 16 studies met the requirements for inclusion after being screened for eligibility. RESULTS: The Simpson index was the only diversity measure shown to be considerably lower in patients with GD compared to healthy participants, whereas all other indices were found to be significantly greater in patients with HT. The latter group, however, showed a greater relative abundance of Bacteroidetes and Actinobacteria at the phylum level, and consequently of Prevotella and Bifidobacterium at the genus level. The strongest positive and negative relationships were seen for thyroid peroxidase antibodies and bacterial load. CONCLUSION: Overall, both GD and HT patients showed significant changes in the gut microbiota's diversity and composition. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023432455.
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spelling pubmed-106418212023-11-14 Exploring the role of gut microbiota in autoimmune thyroid disorders: a systematic review and meta-analysis Alkader, Dania Akeil Abed Asadi, Naweedullah Solangi, Uzma Singh, Ransherjit Rasuli, Sayed Farhad Farooq, Muhammad Jawad Raheela, F. N. U. Waseem, Radeyah Gilani, Syed Mujahid Abbas, Kiran Ahmed, Moiz Tanoh, Desmond Boakye Shah, Hussain Haider Dulal, Ayusha Hussain, Muhammad Sheheryar Talpur, Abdul Subhan Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Autoimmune thyroid diseases (AITDs) are characterized by unique immune responses against thyroid antigens and persist over time. The most common types of AITDs are Graves' disease (GD) and Hashimoto's thyroiditis (HT). There is mounting evidence that changes in the microbiota may play a role in the onset and development of AITDs. OBJECTIVE: The purpose of this comprehensive literature study was to answer the following query: Is there a difference in microbiota in those who have AITDs? METHODS: According to the standards set out by the PRISMA statement, 16 studies met the requirements for inclusion after being screened for eligibility. RESULTS: The Simpson index was the only diversity measure shown to be considerably lower in patients with GD compared to healthy participants, whereas all other indices were found to be significantly greater in patients with HT. The latter group, however, showed a greater relative abundance of Bacteroidetes and Actinobacteria at the phylum level, and consequently of Prevotella and Bifidobacterium at the genus level. The strongest positive and negative relationships were seen for thyroid peroxidase antibodies and bacterial load. CONCLUSION: Overall, both GD and HT patients showed significant changes in the gut microbiota's diversity and composition. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023432455. Frontiers Media S.A. 2023-10-27 /pmc/articles/PMC10641821/ /pubmed/37964972 http://dx.doi.org/10.3389/fendo.2023.1238146 Text en Copyright © 2023 Alkader, Asadi, Solangi, Singh, Rasuli, Farooq, Raheela, Waseem, Gilani, Abbas, Ahmed, Tanoh, Shah, Dulal, Hussain and Talpur https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Alkader, Dania Akeil Abed
Asadi, Naweedullah
Solangi, Uzma
Singh, Ransherjit
Rasuli, Sayed Farhad
Farooq, Muhammad Jawad
Raheela, F. N. U.
Waseem, Radeyah
Gilani, Syed Mujahid
Abbas, Kiran
Ahmed, Moiz
Tanoh, Desmond Boakye
Shah, Hussain Haider
Dulal, Ayusha
Hussain, Muhammad Sheheryar
Talpur, Abdul Subhan
Exploring the role of gut microbiota in autoimmune thyroid disorders: a systematic review and meta-analysis
title Exploring the role of gut microbiota in autoimmune thyroid disorders: a systematic review and meta-analysis
title_full Exploring the role of gut microbiota in autoimmune thyroid disorders: a systematic review and meta-analysis
title_fullStr Exploring the role of gut microbiota in autoimmune thyroid disorders: a systematic review and meta-analysis
title_full_unstemmed Exploring the role of gut microbiota in autoimmune thyroid disorders: a systematic review and meta-analysis
title_short Exploring the role of gut microbiota in autoimmune thyroid disorders: a systematic review and meta-analysis
title_sort exploring the role of gut microbiota in autoimmune thyroid disorders: a systematic review and meta-analysis
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641821/
https://www.ncbi.nlm.nih.gov/pubmed/37964972
http://dx.doi.org/10.3389/fendo.2023.1238146
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