Development of Fluorescent AF64394 Analogues Enables Real-Time Binding Studies for the Orphan Class A GPCR GPR3

[Image: see text] The orphan G protein-coupled receptor (oGPCR) GPR3 represents a potential drug target for the treatment of Alzheimer’s disease and metabolic disorders. However, the limited toolbox of pharmacological assays hampers the development of advanced ligands. Here, we developed a signaling...

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Detalles Bibliográficos
Autores principales: Bresinsky, Merlin, Shahraki, Aida, Kolb, Peter, Pockes, Steffen, Schihada, Hannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641823/
https://www.ncbi.nlm.nih.gov/pubmed/37907069
http://dx.doi.org/10.1021/acs.jmedchem.3c01707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641823/
https://www.ncbi.nlm.nih.gov/pubmed/37907069
http://dx.doi.org/10.1021/acs.jmedchem.3c01707

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