Synthesis and Conformational Analysis of FR901464-Based RNA Splicing Modulators and Their Synergism in Drug-Resistant Cancers

[Image: see text] FR901464 is a cytotoxic natural product that binds splicing factor 3B subunit 1 (SF3B1) and PHD finger protein 5A (PHF5A), the components of the human spliceosome. The amide-containing tetrahydropyran ring binds SF3B1, and it remains unclear how the substituents on the ring contrib...

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Detalles Bibliográficos
Autores principales: Beard, Jacob P., Bressin, Robert K., Markaj, Paulo L., Schmitz, John C., Koide, Kazunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641826/
https://www.ncbi.nlm.nih.gov/pubmed/37870431
http://dx.doi.org/10.1021/acs.jmedchem.3c00733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641826/
https://www.ncbi.nlm.nih.gov/pubmed/37870431
http://dx.doi.org/10.1021/acs.jmedchem.3c00733

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