Alkyl gallates inhibit serine O-acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics

A principal concept in developing antibacterial agents with selective toxicity is blocking metabolic pathways that are critical for bacterial growth but that mammalian cells lack. Serine O-acetyltransferase (CysE) is an enzyme in many bacteria that catalyzes the first step in l-cysteine biosynthesis...

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Detalles Bibliográficos
Autores principales: Toyomoto, Touya, Ono, Katsuhiko, Shiba, Tomoo, Momitani, Kenta, Zhang, Tianli, Tsutsuki, Hiroyasu, Ishikawa, Takeshi, Hoso, Kanae, Hamada, Koma, Rahman, Azizur, Wen, Liping, Maeda, Yosuke, Yamamoto, Keiichi, Matsuoka, Masao, Hanaoka, Kenjiro, Niidome, Takuro, Akaike, Takaaki, Sawa, Tomohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641863/
https://www.ncbi.nlm.nih.gov/pubmed/37965540
http://dx.doi.org/10.3389/fmicb.2023.1276447

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