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Ultra-sensitive CTC-based liquid biopsy for pancreatic cancer enabled by large blood volume analysis

The limited sensitivity of circulating tumor cell (CTC) detection in pancreatic adenocarcinoma (PDAC) stems from their extremely low concentration in the whole circulating blood, necessitating enhanced detection methodologies. This study sought to amplify assay-sensitivity by employing diagnostic le...

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Detalles Bibliográficos
Autores principales: Stoecklein, Nikolas H., Fluegen, Georg, Guglielmi, Rosa, Neves, Rui P.L., Hackert, Thilo, Birgin, Emrullah, Cieslik, Stefan A., Sudarsanam, Monica, Driemel, Christiane, van Dalum, Guus, Franken, André, Niederacher, Dieter, Neubauer, Hans, Fehm, Tanja, Rox, Jutta M., Böhme, Petra, Häberle, Lena, Göring, Wolfgang, Esposito, Irene, Topp, Stefan A., Coumans, Frank A.W., Weitz, Jürgen, Knoefel, Wolfram T., Fischer, Johannes C., Bork, Ulrich, Rahbari, Nuh N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10641981/
https://www.ncbi.nlm.nih.gov/pubmed/37957606
http://dx.doi.org/10.1186/s12943-023-01880-1