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Statistical modeling to quantify the uncertainty of FoldX-predicted protein folding and binding stability
BACKGROUND: Computational methods of predicting protein stability changes upon missense mutations are invaluable tools in high-throughput studies involving a large number of protein variants. However, they are limited by a wide variation in accuracy and difficulty of assessing prediction uncertainty...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642056/ https://www.ncbi.nlm.nih.gov/pubmed/37953256 http://dx.doi.org/10.1186/s12859-023-05537-0 |