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Subcutaneous device-free islet transplantation

Diabetes mellitus is a chronic metabolic disease, characterized by high blood sugar levels; it affects more than 500 million individuals worldwide. Type 1 diabetes mellitus (T1DM) is results from insufficient insulin secretion by islets; its treatment requires lifelong use of insulin injections, whi...

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Autores principales: Zhou, Xudong, Xu, Zhiran, You, Yanqiu, Yang, Wangrong, Feng, BingZheng, Yang, Yuwei, Li, Fujun, Chen, Jibing, Gao, Hongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642112/
https://www.ncbi.nlm.nih.gov/pubmed/37965322
http://dx.doi.org/10.3389/fimmu.2023.1287182
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author Zhou, Xudong
Xu, Zhiran
You, Yanqiu
Yang, Wangrong
Feng, BingZheng
Yang, Yuwei
Li, Fujun
Chen, Jibing
Gao, Hongjun
author_facet Zhou, Xudong
Xu, Zhiran
You, Yanqiu
Yang, Wangrong
Feng, BingZheng
Yang, Yuwei
Li, Fujun
Chen, Jibing
Gao, Hongjun
author_sort Zhou, Xudong
collection PubMed
description Diabetes mellitus is a chronic metabolic disease, characterized by high blood sugar levels; it affects more than 500 million individuals worldwide. Type 1 diabetes mellitus (T1DM) is results from insufficient insulin secretion by islets; its treatment requires lifelong use of insulin injections, which leads to a large economic burden on patients. Islet transplantation may be a promising effective treatment for T1DM. Clinically, this process currently involves directly infusing islet cells into the hepatic portal vein; however, transplantation at this site often elicits immediate blood-mediated inflammatory and acute immune responses. Subcutaneous islet transplantation is an attractive alternative to islet transplantation because it is simpler, demonstrates lower surgical complication risks, and enables graft monitoring and removal. In this article, we review the current methods of subcutaneous device-free islet transplantation. Recent subcutaneous islet transplantation techniques with high success rate have involved the use of bioengineering technology and biomaterial cotransplantation—including cell and cell growth factor co-transplantation and hydrogel– or simulated extracellular matrix–wrapped subcutaneous co-transplantation. In general, current subcutaneous device-free islet transplantation modalities can simplify the surgical process and improve the posttransplantation graft survival rate, thus aiding effective T1DM management.
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spelling pubmed-106421122023-11-14 Subcutaneous device-free islet transplantation Zhou, Xudong Xu, Zhiran You, Yanqiu Yang, Wangrong Feng, BingZheng Yang, Yuwei Li, Fujun Chen, Jibing Gao, Hongjun Front Immunol Immunology Diabetes mellitus is a chronic metabolic disease, characterized by high blood sugar levels; it affects more than 500 million individuals worldwide. Type 1 diabetes mellitus (T1DM) is results from insufficient insulin secretion by islets; its treatment requires lifelong use of insulin injections, which leads to a large economic burden on patients. Islet transplantation may be a promising effective treatment for T1DM. Clinically, this process currently involves directly infusing islet cells into the hepatic portal vein; however, transplantation at this site often elicits immediate blood-mediated inflammatory and acute immune responses. Subcutaneous islet transplantation is an attractive alternative to islet transplantation because it is simpler, demonstrates lower surgical complication risks, and enables graft monitoring and removal. In this article, we review the current methods of subcutaneous device-free islet transplantation. Recent subcutaneous islet transplantation techniques with high success rate have involved the use of bioengineering technology and biomaterial cotransplantation—including cell and cell growth factor co-transplantation and hydrogel– or simulated extracellular matrix–wrapped subcutaneous co-transplantation. In general, current subcutaneous device-free islet transplantation modalities can simplify the surgical process and improve the posttransplantation graft survival rate, thus aiding effective T1DM management. Frontiers Media S.A. 2023-10-18 /pmc/articles/PMC10642112/ /pubmed/37965322 http://dx.doi.org/10.3389/fimmu.2023.1287182 Text en Copyright © 2023 Zhou, Xu, You, Yang, Feng, Yang, Li, Chen and Gao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhou, Xudong
Xu, Zhiran
You, Yanqiu
Yang, Wangrong
Feng, BingZheng
Yang, Yuwei
Li, Fujun
Chen, Jibing
Gao, Hongjun
Subcutaneous device-free islet transplantation
title Subcutaneous device-free islet transplantation
title_full Subcutaneous device-free islet transplantation
title_fullStr Subcutaneous device-free islet transplantation
title_full_unstemmed Subcutaneous device-free islet transplantation
title_short Subcutaneous device-free islet transplantation
title_sort subcutaneous device-free islet transplantation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642112/
https://www.ncbi.nlm.nih.gov/pubmed/37965322
http://dx.doi.org/10.3389/fimmu.2023.1287182
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