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Subcutaneous device-free islet transplantation
Diabetes mellitus is a chronic metabolic disease, characterized by high blood sugar levels; it affects more than 500 million individuals worldwide. Type 1 diabetes mellitus (T1DM) is results from insufficient insulin secretion by islets; its treatment requires lifelong use of insulin injections, whi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642112/ https://www.ncbi.nlm.nih.gov/pubmed/37965322 http://dx.doi.org/10.3389/fimmu.2023.1287182 |
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author | Zhou, Xudong Xu, Zhiran You, Yanqiu Yang, Wangrong Feng, BingZheng Yang, Yuwei Li, Fujun Chen, Jibing Gao, Hongjun |
author_facet | Zhou, Xudong Xu, Zhiran You, Yanqiu Yang, Wangrong Feng, BingZheng Yang, Yuwei Li, Fujun Chen, Jibing Gao, Hongjun |
author_sort | Zhou, Xudong |
collection | PubMed |
description | Diabetes mellitus is a chronic metabolic disease, characterized by high blood sugar levels; it affects more than 500 million individuals worldwide. Type 1 diabetes mellitus (T1DM) is results from insufficient insulin secretion by islets; its treatment requires lifelong use of insulin injections, which leads to a large economic burden on patients. Islet transplantation may be a promising effective treatment for T1DM. Clinically, this process currently involves directly infusing islet cells into the hepatic portal vein; however, transplantation at this site often elicits immediate blood-mediated inflammatory and acute immune responses. Subcutaneous islet transplantation is an attractive alternative to islet transplantation because it is simpler, demonstrates lower surgical complication risks, and enables graft monitoring and removal. In this article, we review the current methods of subcutaneous device-free islet transplantation. Recent subcutaneous islet transplantation techniques with high success rate have involved the use of bioengineering technology and biomaterial cotransplantation—including cell and cell growth factor co-transplantation and hydrogel– or simulated extracellular matrix–wrapped subcutaneous co-transplantation. In general, current subcutaneous device-free islet transplantation modalities can simplify the surgical process and improve the posttransplantation graft survival rate, thus aiding effective T1DM management. |
format | Online Article Text |
id | pubmed-10642112 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106421122023-11-14 Subcutaneous device-free islet transplantation Zhou, Xudong Xu, Zhiran You, Yanqiu Yang, Wangrong Feng, BingZheng Yang, Yuwei Li, Fujun Chen, Jibing Gao, Hongjun Front Immunol Immunology Diabetes mellitus is a chronic metabolic disease, characterized by high blood sugar levels; it affects more than 500 million individuals worldwide. Type 1 diabetes mellitus (T1DM) is results from insufficient insulin secretion by islets; its treatment requires lifelong use of insulin injections, which leads to a large economic burden on patients. Islet transplantation may be a promising effective treatment for T1DM. Clinically, this process currently involves directly infusing islet cells into the hepatic portal vein; however, transplantation at this site often elicits immediate blood-mediated inflammatory and acute immune responses. Subcutaneous islet transplantation is an attractive alternative to islet transplantation because it is simpler, demonstrates lower surgical complication risks, and enables graft monitoring and removal. In this article, we review the current methods of subcutaneous device-free islet transplantation. Recent subcutaneous islet transplantation techniques with high success rate have involved the use of bioengineering technology and biomaterial cotransplantation—including cell and cell growth factor co-transplantation and hydrogel– or simulated extracellular matrix–wrapped subcutaneous co-transplantation. In general, current subcutaneous device-free islet transplantation modalities can simplify the surgical process and improve the posttransplantation graft survival rate, thus aiding effective T1DM management. Frontiers Media S.A. 2023-10-18 /pmc/articles/PMC10642112/ /pubmed/37965322 http://dx.doi.org/10.3389/fimmu.2023.1287182 Text en Copyright © 2023 Zhou, Xu, You, Yang, Feng, Yang, Li, Chen and Gao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhou, Xudong Xu, Zhiran You, Yanqiu Yang, Wangrong Feng, BingZheng Yang, Yuwei Li, Fujun Chen, Jibing Gao, Hongjun Subcutaneous device-free islet transplantation |
title | Subcutaneous device-free islet transplantation |
title_full | Subcutaneous device-free islet transplantation |
title_fullStr | Subcutaneous device-free islet transplantation |
title_full_unstemmed | Subcutaneous device-free islet transplantation |
title_short | Subcutaneous device-free islet transplantation |
title_sort | subcutaneous device-free islet transplantation |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642112/ https://www.ncbi.nlm.nih.gov/pubmed/37965322 http://dx.doi.org/10.3389/fimmu.2023.1287182 |
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