The brain protection of MLKL inhibitor necrosulfonamide against focal ischemia/reperfusion injury associating with blocking the nucleus and nuclear envelope translocation of MLKL and RIP3K

Mixed lineage kinase like protein (MLKL) is a key mediator of necroptosis. While previous studies highlighted the important role of MLKL as one of the central regulators of brain damage against acute ischemic neuronal injury, how the activation of MLKL mediates brain injuries and cell death remains...

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Detalles Bibliográficos
Autores principales: Zhou, Xian-Yong, Lin, Bo, Chen, Wei, Cao, Rui-Qi, Guo, Yi, Said, Ali, Khan, Taous, Zhang, Hui-Ling, Zhu, Yong-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642205/
https://www.ncbi.nlm.nih.gov/pubmed/37964865
http://dx.doi.org/10.3389/fphar.2023.1157054

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