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Association among β2‐adrenergic receptor autoantibodies and proximal left anterior descending artery lesions in patients with initial ST‐segment elevation myocardial infarction

BACKGROUND: β(2)‐adrenergic receptor autoantibody (β(2)‐AA) are widely present in patients with many different types of cardiovascular diseases. Proximal left anterior descending (LAD) artery lesions are associated with adverse prognostic events in patients with ST‐segment elevation myocardial infar...

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Autores principales: Dang, Wenxi, Cao, Ning, Zhang, Yue, Li, Weiping, Li, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642316/
https://www.ncbi.nlm.nih.gov/pubmed/37587904
http://dx.doi.org/10.1002/clc.24129
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author Dang, Wenxi
Cao, Ning
Zhang, Yue
Li, Weiping
Li, Hongwei
author_facet Dang, Wenxi
Cao, Ning
Zhang, Yue
Li, Weiping
Li, Hongwei
author_sort Dang, Wenxi
collection PubMed
description BACKGROUND: β(2)‐adrenergic receptor autoantibody (β(2)‐AA) are widely present in patients with many different types of cardiovascular diseases. Proximal left anterior descending (LAD) artery lesions are associated with adverse prognostic events in patients with ST‐segment elevation myocardial infarction (STEMI). HYPOTHESIS: β(2)‐AA is associated with the presence of proximal LAD lesions in patients with STEMI. METHODS: A cohort of 153 patients with STEMI who underwent primary percutaneous coronary intervention (PPCI) was enrolled in the study. Baseline characteristics were compared between the proximal LAD group (n = 62) and the nonproximal LAD group (n = 91). Admission serum of patients was collected to detect the level of β(2)‐AA. Data for echocardiogram within 24 hours after PPCI and at the 6‐month follow‐up were recorded. RESULTS: The optical density values and positive rates of β(2)‐AA in the proximal LAD group were higher than those in the nonproximal LAD group (p < 0.05). β(2)‐AA positively correlated with high sensitivity C‐reactive protein and peak N‐terminal pro‐B type natriuretic peptide levels in the proximal LAD group, but those were not relevant in the nonproximal LAD group. Multivariate logistic regression analysis revealed that high β(2)‐AA levels was independently associated with the presence of proximal LAD lesions in patients with STEMI. Furthermore, a receiver operating characteristic curve was used to show the efficiency of β(2)‐AA levels to detect proximal LAD lesions, and the AUC of the β2‐AA OD value was 0.658 (95% confidence interval 0.568−0.749; p = 0.001). CONCLUSIONS: The STEMI patients with high β(2)‐AA levels had a greater possibility having proximal LAD lesions.
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spelling pubmed-106423162023-11-15 Association among β2‐adrenergic receptor autoantibodies and proximal left anterior descending artery lesions in patients with initial ST‐segment elevation myocardial infarction Dang, Wenxi Cao, Ning Zhang, Yue Li, Weiping Li, Hongwei Clin Cardiol Clinical Investigations BACKGROUND: β(2)‐adrenergic receptor autoantibody (β(2)‐AA) are widely present in patients with many different types of cardiovascular diseases. Proximal left anterior descending (LAD) artery lesions are associated with adverse prognostic events in patients with ST‐segment elevation myocardial infarction (STEMI). HYPOTHESIS: β(2)‐AA is associated with the presence of proximal LAD lesions in patients with STEMI. METHODS: A cohort of 153 patients with STEMI who underwent primary percutaneous coronary intervention (PPCI) was enrolled in the study. Baseline characteristics were compared between the proximal LAD group (n = 62) and the nonproximal LAD group (n = 91). Admission serum of patients was collected to detect the level of β(2)‐AA. Data for echocardiogram within 24 hours after PPCI and at the 6‐month follow‐up were recorded. RESULTS: The optical density values and positive rates of β(2)‐AA in the proximal LAD group were higher than those in the nonproximal LAD group (p < 0.05). β(2)‐AA positively correlated with high sensitivity C‐reactive protein and peak N‐terminal pro‐B type natriuretic peptide levels in the proximal LAD group, but those were not relevant in the nonproximal LAD group. Multivariate logistic regression analysis revealed that high β(2)‐AA levels was independently associated with the presence of proximal LAD lesions in patients with STEMI. Furthermore, a receiver operating characteristic curve was used to show the efficiency of β(2)‐AA levels to detect proximal LAD lesions, and the AUC of the β2‐AA OD value was 0.658 (95% confidence interval 0.568−0.749; p = 0.001). CONCLUSIONS: The STEMI patients with high β(2)‐AA levels had a greater possibility having proximal LAD lesions. John Wiley and Sons Inc. 2023-08-17 /pmc/articles/PMC10642316/ /pubmed/37587904 http://dx.doi.org/10.1002/clc.24129 Text en © 2023 The Authors. Clinical Cardiology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigations
Dang, Wenxi
Cao, Ning
Zhang, Yue
Li, Weiping
Li, Hongwei
Association among β2‐adrenergic receptor autoantibodies and proximal left anterior descending artery lesions in patients with initial ST‐segment elevation myocardial infarction
title Association among β2‐adrenergic receptor autoantibodies and proximal left anterior descending artery lesions in patients with initial ST‐segment elevation myocardial infarction
title_full Association among β2‐adrenergic receptor autoantibodies and proximal left anterior descending artery lesions in patients with initial ST‐segment elevation myocardial infarction
title_fullStr Association among β2‐adrenergic receptor autoantibodies and proximal left anterior descending artery lesions in patients with initial ST‐segment elevation myocardial infarction
title_full_unstemmed Association among β2‐adrenergic receptor autoantibodies and proximal left anterior descending artery lesions in patients with initial ST‐segment elevation myocardial infarction
title_short Association among β2‐adrenergic receptor autoantibodies and proximal left anterior descending artery lesions in patients with initial ST‐segment elevation myocardial infarction
title_sort association among β2‐adrenergic receptor autoantibodies and proximal left anterior descending artery lesions in patients with initial st‐segment elevation myocardial infarction
topic Clinical Investigations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642316/
https://www.ncbi.nlm.nih.gov/pubmed/37587904
http://dx.doi.org/10.1002/clc.24129
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