Autoantibodies from patients with kidney allograft vasculopathy stimulate a proinflammatory switch in endothelial cells and monocytes mediated via GPCR-directed PAR1-TNF-α signaling

Non-HLA-directed regulatory autoantibodies (RABs) are known to target G-protein coupled receptors (GPCRs) and thereby contribute to kidney transplant vasculopathy and failure. However, the detailed underlying signaling mechanisms in human microvascular endothelial cells (HMECs) and immune cells need...

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Detalles Bibliográficos
Autores principales: Moll, Guido, Luecht, Christian, Gyamfi, Michael Adu, da Fonseca, Dennyson L. M., Wang, Pinchao, Zhao, Hongfan, Gong, Zexian, Chen, Lei, Ashraf, Muhamad Imtiaz, Heidecke, Harald, Hackel, Alexander Maximilian, Dragun, Duska, Budde, Klemens, Penack, Olaf, Riemekasten, Gabriela, Cabral-Marques, Otávio, Witowski, Janusz, Catar, Rusan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642342/
https://www.ncbi.nlm.nih.gov/pubmed/37965310
http://dx.doi.org/10.3389/fimmu.2023.1289744

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