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Role of glycolysis in diabetic atherosclerosis
Diabetes mellitus is a kind of typical metabolic disorder characterized by elevated blood sugar levels. Atherosclerosis (AS) is one of the most common complications of diabetes. Modern lifestyles and trends that promote overconsumption and unhealthy practices have contributed to an increase in the a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642412/ https://www.ncbi.nlm.nih.gov/pubmed/37970130 http://dx.doi.org/10.4239/wjd.v14.i10.1478 |
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author | Liu, Qian-Jia Yuan, Wei Yang, Ping Shao, Chen |
author_facet | Liu, Qian-Jia Yuan, Wei Yang, Ping Shao, Chen |
author_sort | Liu, Qian-Jia |
collection | PubMed |
description | Diabetes mellitus is a kind of typical metabolic disorder characterized by elevated blood sugar levels. Atherosclerosis (AS) is one of the most common complications of diabetes. Modern lifestyles and trends that promote overconsumption and unhealthy practices have contributed to an increase in the annual incidence of diabetic AS worldwide, which has created a heavy burden on society. Several studies have shown the significant effects of glycolysis-related changes on the occurrence and development of diabetic AS, which may serve as novel thera-peutic targets for diabetic AS in the future. Glycolysis is an important metabolic pathway that generates energy in various cells of the blood vessel wall. In particular, it plays a vital role in the physiological and pathological activities of the three important cells, Endothelial cells, macrophages and vascular smooth muscle cells. There are lots of similar mechanisms underlying diabetic and common AS, the former is more complex. In this article, we describe the role and mechanism underlying glycolysis in diabetic AS, as well as the therapeutic targets, such as trained immunity, microRNAs, gut microbiota, and associated drugs, with the aim to provide some new perspectives and potentially feasible programs for the treatment of diabetic AS in the foreseeable future. |
format | Online Article Text |
id | pubmed-10642412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-106424122023-11-15 Role of glycolysis in diabetic atherosclerosis Liu, Qian-Jia Yuan, Wei Yang, Ping Shao, Chen World J Diabetes Review Diabetes mellitus is a kind of typical metabolic disorder characterized by elevated blood sugar levels. Atherosclerosis (AS) is one of the most common complications of diabetes. Modern lifestyles and trends that promote overconsumption and unhealthy practices have contributed to an increase in the annual incidence of diabetic AS worldwide, which has created a heavy burden on society. Several studies have shown the significant effects of glycolysis-related changes on the occurrence and development of diabetic AS, which may serve as novel thera-peutic targets for diabetic AS in the future. Glycolysis is an important metabolic pathway that generates energy in various cells of the blood vessel wall. In particular, it plays a vital role in the physiological and pathological activities of the three important cells, Endothelial cells, macrophages and vascular smooth muscle cells. There are lots of similar mechanisms underlying diabetic and common AS, the former is more complex. In this article, we describe the role and mechanism underlying glycolysis in diabetic AS, as well as the therapeutic targets, such as trained immunity, microRNAs, gut microbiota, and associated drugs, with the aim to provide some new perspectives and potentially feasible programs for the treatment of diabetic AS in the foreseeable future. Baishideng Publishing Group Inc 2023-10-15 2023-10-15 /pmc/articles/PMC10642412/ /pubmed/37970130 http://dx.doi.org/10.4239/wjd.v14.i10.1478 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Review Liu, Qian-Jia Yuan, Wei Yang, Ping Shao, Chen Role of glycolysis in diabetic atherosclerosis |
title | Role of glycolysis in diabetic atherosclerosis |
title_full | Role of glycolysis in diabetic atherosclerosis |
title_fullStr | Role of glycolysis in diabetic atherosclerosis |
title_full_unstemmed | Role of glycolysis in diabetic atherosclerosis |
title_short | Role of glycolysis in diabetic atherosclerosis |
title_sort | role of glycolysis in diabetic atherosclerosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642412/ https://www.ncbi.nlm.nih.gov/pubmed/37970130 http://dx.doi.org/10.4239/wjd.v14.i10.1478 |
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