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Partners in diabetes epidemic: A global perspective
There is a recent increase in the worldwide prevalence of both obesity and diabetes. In this review we assessed insulin signaling, genetics, environment, lipid metabolism dysfunction and mitochondria as the major determinants in diabetes and to identify the potential mechanism of gut microbiota in d...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642420/ https://www.ncbi.nlm.nih.gov/pubmed/37970124 http://dx.doi.org/10.4239/wjd.v14.i10.1463 |
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author | Wang, Huan Akbari-Alavijeh, Safoura Parhar, Ranjit S Gaugler, Randy Hashmi, Sarwar |
author_facet | Wang, Huan Akbari-Alavijeh, Safoura Parhar, Ranjit S Gaugler, Randy Hashmi, Sarwar |
author_sort | Wang, Huan |
collection | PubMed |
description | There is a recent increase in the worldwide prevalence of both obesity and diabetes. In this review we assessed insulin signaling, genetics, environment, lipid metabolism dysfunction and mitochondria as the major determinants in diabetes and to identify the potential mechanism of gut microbiota in diabetes diseases. We searched relevant articles, which have key information from laboratory experiments, epidemiological evidence, clinical trials, experimental models, meta-analysis and review articles, in PubMed, MEDLINE, EMBASE, Google scholars and Cochrane Controlled Trial Database. We selected 144 full-length articles that met our inclusion and exclusion criteria for complete assessment. We have briefly discussed these associations, challenges, and the need for further research to manage and treat diabetes more efficiently. Diabetes involves the complex network of physiological dysfunction that can be attributed to insulin signaling, genetics, environment, obesity, mitochondria and stress. In recent years, there are intriguing findings regarding gut microbiome as the important regulator of diabetes. Valid approaches are necessary for speeding medical advances but we should find a solution sooner given the burden of the metabolic disorder ― What we need is a collaborative venture that may involve laboratories both in academia and industries for the scientific progress and its application for the diabetes control. |
format | Online Article Text |
id | pubmed-10642420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-106424202023-11-15 Partners in diabetes epidemic: A global perspective Wang, Huan Akbari-Alavijeh, Safoura Parhar, Ranjit S Gaugler, Randy Hashmi, Sarwar World J Diabetes Review There is a recent increase in the worldwide prevalence of both obesity and diabetes. In this review we assessed insulin signaling, genetics, environment, lipid metabolism dysfunction and mitochondria as the major determinants in diabetes and to identify the potential mechanism of gut microbiota in diabetes diseases. We searched relevant articles, which have key information from laboratory experiments, epidemiological evidence, clinical trials, experimental models, meta-analysis and review articles, in PubMed, MEDLINE, EMBASE, Google scholars and Cochrane Controlled Trial Database. We selected 144 full-length articles that met our inclusion and exclusion criteria for complete assessment. We have briefly discussed these associations, challenges, and the need for further research to manage and treat diabetes more efficiently. Diabetes involves the complex network of physiological dysfunction that can be attributed to insulin signaling, genetics, environment, obesity, mitochondria and stress. In recent years, there are intriguing findings regarding gut microbiome as the important regulator of diabetes. Valid approaches are necessary for speeding medical advances but we should find a solution sooner given the burden of the metabolic disorder ― What we need is a collaborative venture that may involve laboratories both in academia and industries for the scientific progress and its application for the diabetes control. Baishideng Publishing Group Inc 2023-10-15 2023-10-15 /pmc/articles/PMC10642420/ /pubmed/37970124 http://dx.doi.org/10.4239/wjd.v14.i10.1463 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Review Wang, Huan Akbari-Alavijeh, Safoura Parhar, Ranjit S Gaugler, Randy Hashmi, Sarwar Partners in diabetes epidemic: A global perspective |
title | Partners in diabetes epidemic: A global perspective |
title_full | Partners in diabetes epidemic: A global perspective |
title_fullStr | Partners in diabetes epidemic: A global perspective |
title_full_unstemmed | Partners in diabetes epidemic: A global perspective |
title_short | Partners in diabetes epidemic: A global perspective |
title_sort | partners in diabetes epidemic: a global perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642420/ https://www.ncbi.nlm.nih.gov/pubmed/37970124 http://dx.doi.org/10.4239/wjd.v14.i10.1463 |
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