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Progress on traditional Chinese medicine in improving hepatic fibrosis through inhibiting oxidative stress

Hepatic fibrosis is a common pathological process that occurs in the development of various chronic liver diseases into cirrhosis and liver cancer, characterized by excessive deposition of the extracellular matrix. In the past, hepatic fibrosis was thought to be a static and irreversible pathologica...

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Autores principales: Li, Zhen, Zhu, Jun-Feng, Ouyang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642434/
https://www.ncbi.nlm.nih.gov/pubmed/37970620
http://dx.doi.org/10.4254/wjh.v15.i10.1091
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author Li, Zhen
Zhu, Jun-Feng
Ouyang, Hao
author_facet Li, Zhen
Zhu, Jun-Feng
Ouyang, Hao
author_sort Li, Zhen
collection PubMed
description Hepatic fibrosis is a common pathological process that occurs in the development of various chronic liver diseases into cirrhosis and liver cancer, characterized by excessive deposition of the extracellular matrix. In the past, hepatic fibrosis was thought to be a static and irreversible pathological process. In recent years, with the rapid development of molecular biology and the continuous in-depth study of the liver at the microscopic level, more and more evidence has shown that hepatic fibrosis is a dynamic and reversible process. Therefore, it is particularly important to find an effective, simple, and inexpensive method for its prevention and treatment. Traditional Chinese medicine (TCM) occupies an important position in the treatment of hepatic fibrosis due to its advantages of low adverse reactions, low cost, and multi-target effectiveness. A large number of research results have shown that TCM monomers, single herbal extracts, and TCM formulas play important roles in the prevention and treatment of hepatic fibrosis. Oxidative stress (OS) is one of the key factors in the occurrence and development of hepatic fibrosis. Therefore, this article reviews the progress in the understanding of the mechanisms of TCM monomers, single herbal extracts, and TCM formulas in preventing and treating hepatic fibrosis by inhibiting OS in recent years, in order to provide a reference and basis for drug therapy of hepatic fibrosis.
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spelling pubmed-106424342023-11-15 Progress on traditional Chinese medicine in improving hepatic fibrosis through inhibiting oxidative stress Li, Zhen Zhu, Jun-Feng Ouyang, Hao World J Hepatol Review Hepatic fibrosis is a common pathological process that occurs in the development of various chronic liver diseases into cirrhosis and liver cancer, characterized by excessive deposition of the extracellular matrix. In the past, hepatic fibrosis was thought to be a static and irreversible pathological process. In recent years, with the rapid development of molecular biology and the continuous in-depth study of the liver at the microscopic level, more and more evidence has shown that hepatic fibrosis is a dynamic and reversible process. Therefore, it is particularly important to find an effective, simple, and inexpensive method for its prevention and treatment. Traditional Chinese medicine (TCM) occupies an important position in the treatment of hepatic fibrosis due to its advantages of low adverse reactions, low cost, and multi-target effectiveness. A large number of research results have shown that TCM monomers, single herbal extracts, and TCM formulas play important roles in the prevention and treatment of hepatic fibrosis. Oxidative stress (OS) is one of the key factors in the occurrence and development of hepatic fibrosis. Therefore, this article reviews the progress in the understanding of the mechanisms of TCM monomers, single herbal extracts, and TCM formulas in preventing and treating hepatic fibrosis by inhibiting OS in recent years, in order to provide a reference and basis for drug therapy of hepatic fibrosis. Baishideng Publishing Group Inc 2023-10-27 2023-10-27 /pmc/articles/PMC10642434/ /pubmed/37970620 http://dx.doi.org/10.4254/wjh.v15.i10.1091 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Li, Zhen
Zhu, Jun-Feng
Ouyang, Hao
Progress on traditional Chinese medicine in improving hepatic fibrosis through inhibiting oxidative stress
title Progress on traditional Chinese medicine in improving hepatic fibrosis through inhibiting oxidative stress
title_full Progress on traditional Chinese medicine in improving hepatic fibrosis through inhibiting oxidative stress
title_fullStr Progress on traditional Chinese medicine in improving hepatic fibrosis through inhibiting oxidative stress
title_full_unstemmed Progress on traditional Chinese medicine in improving hepatic fibrosis through inhibiting oxidative stress
title_short Progress on traditional Chinese medicine in improving hepatic fibrosis through inhibiting oxidative stress
title_sort progress on traditional chinese medicine in improving hepatic fibrosis through inhibiting oxidative stress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642434/
https://www.ncbi.nlm.nih.gov/pubmed/37970620
http://dx.doi.org/10.4254/wjh.v15.i10.1091
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