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Epidemiology and treatment of children with hereditary angioedema in Germany: A retrospective database study
BACKGROUND: Hereditary angioedema (HAE) is a potentially life‐threatening inherited disease that causes recurrent, serious, and debilitating episodes of swelling. While evidence has improved in adult patients, data on the epidemiology and treatment of pediatric patients with HAE remain very limited....
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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John Wiley and Sons Inc.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642561/ https://www.ncbi.nlm.nih.gov/pubmed/38006382 http://dx.doi.org/10.1002/clt2.12313 |
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author | Prenzel, Freerk Abraham, Susanne Hirche, Christoph Müller, Gerrit Kaiser, Stephan Serdani‐Neuhaus, Leonarda Zingel, Rebecca Martinez‐Saguer, Inmaculada |
author_facet | Prenzel, Freerk Abraham, Susanne Hirche, Christoph Müller, Gerrit Kaiser, Stephan Serdani‐Neuhaus, Leonarda Zingel, Rebecca Martinez‐Saguer, Inmaculada |
author_sort | Prenzel, Freerk |
collection | PubMed |
description | BACKGROUND: Hereditary angioedema (HAE) is a potentially life‐threatening inherited disease that causes recurrent, serious, and debilitating episodes of swelling. While evidence has improved in adult patients, data on the epidemiology and treatment of pediatric patients with HAE remain very limited. The aim of this study was to determine the incidence and prevalence of pediatric patients with HAE aged <12 years, as well as treatment patterns, co‐medication, and specialties involved. METHODS: In this retrospective study (2016–2021), the German IQVIA(TM) pharmacy claims (LRx) database was used to analyze prescriptions of HAE‐specific treatments and co‐medications. RESULTS: We found an HAE prevalence in pediatric patients aged <12 years of 2.51:100,000 and a 12‐month prevalence of up to 1.02:100,000 between 2016 and 2021. Most HAE treatments were prescribed by outpatient clinics and pediatricians, with an increasing proportion of icatibant as an on‐demand treatment and low rates of long‐term prophylaxis (LTP). The prescription rate of analgesics as the most common co‐medication decreased notably after HAE diagnosis. CONCLUSION: Our findings provide insights into the epidemiology and current pediatric HAE treatment landscape in Germany. The obtained HAE prevalence in pediatric patients aged <12 years was even higher than the previously reported average of overall cohorts, whereas the LTP rate was low, which might indicate an unmet need for newer LTP treatment options in pediatric patients. |
format | Online Article Text |
id | pubmed-10642561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106425612023-11-14 Epidemiology and treatment of children with hereditary angioedema in Germany: A retrospective database study Prenzel, Freerk Abraham, Susanne Hirche, Christoph Müller, Gerrit Kaiser, Stephan Serdani‐Neuhaus, Leonarda Zingel, Rebecca Martinez‐Saguer, Inmaculada Clin Transl Allergy Original Article BACKGROUND: Hereditary angioedema (HAE) is a potentially life‐threatening inherited disease that causes recurrent, serious, and debilitating episodes of swelling. While evidence has improved in adult patients, data on the epidemiology and treatment of pediatric patients with HAE remain very limited. The aim of this study was to determine the incidence and prevalence of pediatric patients with HAE aged <12 years, as well as treatment patterns, co‐medication, and specialties involved. METHODS: In this retrospective study (2016–2021), the German IQVIA(TM) pharmacy claims (LRx) database was used to analyze prescriptions of HAE‐specific treatments and co‐medications. RESULTS: We found an HAE prevalence in pediatric patients aged <12 years of 2.51:100,000 and a 12‐month prevalence of up to 1.02:100,000 between 2016 and 2021. Most HAE treatments were prescribed by outpatient clinics and pediatricians, with an increasing proportion of icatibant as an on‐demand treatment and low rates of long‐term prophylaxis (LTP). The prescription rate of analgesics as the most common co‐medication decreased notably after HAE diagnosis. CONCLUSION: Our findings provide insights into the epidemiology and current pediatric HAE treatment landscape in Germany. The obtained HAE prevalence in pediatric patients aged <12 years was even higher than the previously reported average of overall cohorts, whereas the LTP rate was low, which might indicate an unmet need for newer LTP treatment options in pediatric patients. John Wiley and Sons Inc. 2023-11-13 /pmc/articles/PMC10642561/ /pubmed/38006382 http://dx.doi.org/10.1002/clt2.12313 Text en © 2023 Takeda Pharma and The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Prenzel, Freerk Abraham, Susanne Hirche, Christoph Müller, Gerrit Kaiser, Stephan Serdani‐Neuhaus, Leonarda Zingel, Rebecca Martinez‐Saguer, Inmaculada Epidemiology and treatment of children with hereditary angioedema in Germany: A retrospective database study |
title | Epidemiology and treatment of children with hereditary angioedema in Germany: A retrospective database study |
title_full | Epidemiology and treatment of children with hereditary angioedema in Germany: A retrospective database study |
title_fullStr | Epidemiology and treatment of children with hereditary angioedema in Germany: A retrospective database study |
title_full_unstemmed | Epidemiology and treatment of children with hereditary angioedema in Germany: A retrospective database study |
title_short | Epidemiology and treatment of children with hereditary angioedema in Germany: A retrospective database study |
title_sort | epidemiology and treatment of children with hereditary angioedema in germany: a retrospective database study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642561/ https://www.ncbi.nlm.nih.gov/pubmed/38006382 http://dx.doi.org/10.1002/clt2.12313 |
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