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The emerging role of m(6)A modification of non-coding RNA in gastrointestinal cancers: a comprehensive review

Gastrointestinal (GI) cancer is a series of malignant tumors with a high incidence globally. Although approaches for tumor diagnosis and therapy have advanced substantially, the mechanisms underlying the occurrence and progression of GI cancer are still unclear. Increasing evidence supports an impor...

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Autores principales: Wang, Meiqi, Liu, Zhuo, Fang, Xuedong, Cong, Xianling, Hu, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642577/
https://www.ncbi.nlm.nih.gov/pubmed/37965577
http://dx.doi.org/10.3389/fcell.2023.1264552
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author Wang, Meiqi
Liu, Zhuo
Fang, Xuedong
Cong, Xianling
Hu, Yue
author_facet Wang, Meiqi
Liu, Zhuo
Fang, Xuedong
Cong, Xianling
Hu, Yue
author_sort Wang, Meiqi
collection PubMed
description Gastrointestinal (GI) cancer is a series of malignant tumors with a high incidence globally. Although approaches for tumor diagnosis and therapy have advanced substantially, the mechanisms underlying the occurrence and progression of GI cancer are still unclear. Increasing evidence supports an important role for N(6)-methyladenosine (m(6)A) modification in many biological processes, including cancer-related processes via splicing, export, degradation, and translation of mRNAs. Under distinct cancer contexts, m(6)A regulators have different expression patterns and can regulate or be regulated by mRNAs and non-coding RNAs, especially long non-coding RNAs. The roles of m(6)A in cancer development have attracted increasing attention in epigenetics research. In this review, we synthesize progress in our understanding of m(6)A and its roles in GI cancer, especially esophageal, gastric, and colorectal cancers. Furthermore, we clarify the mechanism by which m(6)A contributes to GI cancer, providing a basis for the development of diagnostic, prognostic, and therapeutic targets.
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spelling pubmed-106425772023-11-14 The emerging role of m(6)A modification of non-coding RNA in gastrointestinal cancers: a comprehensive review Wang, Meiqi Liu, Zhuo Fang, Xuedong Cong, Xianling Hu, Yue Front Cell Dev Biol Cell and Developmental Biology Gastrointestinal (GI) cancer is a series of malignant tumors with a high incidence globally. Although approaches for tumor diagnosis and therapy have advanced substantially, the mechanisms underlying the occurrence and progression of GI cancer are still unclear. Increasing evidence supports an important role for N(6)-methyladenosine (m(6)A) modification in many biological processes, including cancer-related processes via splicing, export, degradation, and translation of mRNAs. Under distinct cancer contexts, m(6)A regulators have different expression patterns and can regulate or be regulated by mRNAs and non-coding RNAs, especially long non-coding RNAs. The roles of m(6)A in cancer development have attracted increasing attention in epigenetics research. In this review, we synthesize progress in our understanding of m(6)A and its roles in GI cancer, especially esophageal, gastric, and colorectal cancers. Furthermore, we clarify the mechanism by which m(6)A contributes to GI cancer, providing a basis for the development of diagnostic, prognostic, and therapeutic targets. Frontiers Media S.A. 2023-10-30 /pmc/articles/PMC10642577/ /pubmed/37965577 http://dx.doi.org/10.3389/fcell.2023.1264552 Text en Copyright © 2023 Wang, Liu, Fang, Cong and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Wang, Meiqi
Liu, Zhuo
Fang, Xuedong
Cong, Xianling
Hu, Yue
The emerging role of m(6)A modification of non-coding RNA in gastrointestinal cancers: a comprehensive review
title The emerging role of m(6)A modification of non-coding RNA in gastrointestinal cancers: a comprehensive review
title_full The emerging role of m(6)A modification of non-coding RNA in gastrointestinal cancers: a comprehensive review
title_fullStr The emerging role of m(6)A modification of non-coding RNA in gastrointestinal cancers: a comprehensive review
title_full_unstemmed The emerging role of m(6)A modification of non-coding RNA in gastrointestinal cancers: a comprehensive review
title_short The emerging role of m(6)A modification of non-coding RNA in gastrointestinal cancers: a comprehensive review
title_sort emerging role of m(6)a modification of non-coding rna in gastrointestinal cancers: a comprehensive review
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642577/
https://www.ncbi.nlm.nih.gov/pubmed/37965577
http://dx.doi.org/10.3389/fcell.2023.1264552
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