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The emerging role of m(6)A modification of non-coding RNA in gastrointestinal cancers: a comprehensive review
Gastrointestinal (GI) cancer is a series of malignant tumors with a high incidence globally. Although approaches for tumor diagnosis and therapy have advanced substantially, the mechanisms underlying the occurrence and progression of GI cancer are still unclear. Increasing evidence supports an impor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642577/ https://www.ncbi.nlm.nih.gov/pubmed/37965577 http://dx.doi.org/10.3389/fcell.2023.1264552 |
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author | Wang, Meiqi Liu, Zhuo Fang, Xuedong Cong, Xianling Hu, Yue |
author_facet | Wang, Meiqi Liu, Zhuo Fang, Xuedong Cong, Xianling Hu, Yue |
author_sort | Wang, Meiqi |
collection | PubMed |
description | Gastrointestinal (GI) cancer is a series of malignant tumors with a high incidence globally. Although approaches for tumor diagnosis and therapy have advanced substantially, the mechanisms underlying the occurrence and progression of GI cancer are still unclear. Increasing evidence supports an important role for N(6)-methyladenosine (m(6)A) modification in many biological processes, including cancer-related processes via splicing, export, degradation, and translation of mRNAs. Under distinct cancer contexts, m(6)A regulators have different expression patterns and can regulate or be regulated by mRNAs and non-coding RNAs, especially long non-coding RNAs. The roles of m(6)A in cancer development have attracted increasing attention in epigenetics research. In this review, we synthesize progress in our understanding of m(6)A and its roles in GI cancer, especially esophageal, gastric, and colorectal cancers. Furthermore, we clarify the mechanism by which m(6)A contributes to GI cancer, providing a basis for the development of diagnostic, prognostic, and therapeutic targets. |
format | Online Article Text |
id | pubmed-10642577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106425772023-11-14 The emerging role of m(6)A modification of non-coding RNA in gastrointestinal cancers: a comprehensive review Wang, Meiqi Liu, Zhuo Fang, Xuedong Cong, Xianling Hu, Yue Front Cell Dev Biol Cell and Developmental Biology Gastrointestinal (GI) cancer is a series of malignant tumors with a high incidence globally. Although approaches for tumor diagnosis and therapy have advanced substantially, the mechanisms underlying the occurrence and progression of GI cancer are still unclear. Increasing evidence supports an important role for N(6)-methyladenosine (m(6)A) modification in many biological processes, including cancer-related processes via splicing, export, degradation, and translation of mRNAs. Under distinct cancer contexts, m(6)A regulators have different expression patterns and can regulate or be regulated by mRNAs and non-coding RNAs, especially long non-coding RNAs. The roles of m(6)A in cancer development have attracted increasing attention in epigenetics research. In this review, we synthesize progress in our understanding of m(6)A and its roles in GI cancer, especially esophageal, gastric, and colorectal cancers. Furthermore, we clarify the mechanism by which m(6)A contributes to GI cancer, providing a basis for the development of diagnostic, prognostic, and therapeutic targets. Frontiers Media S.A. 2023-10-30 /pmc/articles/PMC10642577/ /pubmed/37965577 http://dx.doi.org/10.3389/fcell.2023.1264552 Text en Copyright © 2023 Wang, Liu, Fang, Cong and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Wang, Meiqi Liu, Zhuo Fang, Xuedong Cong, Xianling Hu, Yue The emerging role of m(6)A modification of non-coding RNA in gastrointestinal cancers: a comprehensive review |
title | The emerging role of m(6)A modification of non-coding RNA in gastrointestinal cancers: a comprehensive review |
title_full | The emerging role of m(6)A modification of non-coding RNA in gastrointestinal cancers: a comprehensive review |
title_fullStr | The emerging role of m(6)A modification of non-coding RNA in gastrointestinal cancers: a comprehensive review |
title_full_unstemmed | The emerging role of m(6)A modification of non-coding RNA in gastrointestinal cancers: a comprehensive review |
title_short | The emerging role of m(6)A modification of non-coding RNA in gastrointestinal cancers: a comprehensive review |
title_sort | emerging role of m(6)a modification of non-coding rna in gastrointestinal cancers: a comprehensive review |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642577/ https://www.ncbi.nlm.nih.gov/pubmed/37965577 http://dx.doi.org/10.3389/fcell.2023.1264552 |
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