Azithromycin-Induced Generalized Nonbullous Fixed-Drug Eruption

Azithromycin-induced severe cutaneous reactions occur rare. We report a case of azithromycin-induced generalized nonbullous form of fixed-drug eruption (FDE). A 19-year-old male consulted the dermatology department for multiple painful oval-shaped, sharply defined, and hyperpigmented patches on his chest, abdomen, and upper limbs after consuming oral azithromycin tablets for his sore throat. The generalized nonbullous form of FDE was diagnosed, and the offending drug was stopped immediately. He was treated with antihistamines and steroids, and recovered on follow-up. This FDE is reported due to the spareseness of documentation from South India and to improve the awareness among the prescribing physicians about this severe cutaneous reaction (FDE) for a commonly used drug. This case report gives insight to the clinicians and health-care workers on rare side effects caused by the commonly used antimicrobial agent, azithromycin.