Arrhythmia-associated calmodulin variants interact with KCNQ1 to confer aberrant membrane trafficking and function

Missense variants in calmodulin (CaM) predispose patients to arrhythmias associated with high mortality rates (“calmodulinopathy”). As CaM regulates many key cardiac ion channels, an understanding of disease mechanism associated with CaM variant arrhythmias requires elucidating individual CaM varian...

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Detalles Bibliográficos
Autores principales: Kang, Po wei, Woodbury, Lucy, Angsutararux, Paweorn, Sambare, Namit, Shi, Jingyi, Marras, Martina, Abella, Carlota, Bedi, Anish, Zinn, DeShawn, Cui, Jianmin, Silva, Jonathan R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642763/
https://www.ncbi.nlm.nih.gov/pubmed/37965565
http://dx.doi.org/10.1093/pnasnexus/pgad335

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