Cargando…

Free water imaging unravels unique patterns of longitudinal structural brain changes in Parkinson’s disease subtypes

BACKGROUND: Research shows that individuals with Parkinson’s disease (PD) who have a postural instability and gait difficulties (PIGD) subtype have a faster disease progression compared to those with a tremor dominant (TD) subtype. Nevertheless, our understanding of the structural brain changes cont...

Descripción completa

Detalles Bibliográficos
Autores principales: Bower, Abigail E., Crisomia, Sophia J., Chung, Jae Woo, Martello, Justin P., Burciu, Roxana G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642764/
https://www.ncbi.nlm.nih.gov/pubmed/37965163
http://dx.doi.org/10.3389/fneur.2023.1278065
_version_ 1785147018542317568
author Bower, Abigail E.
Crisomia, Sophia J.
Chung, Jae Woo
Martello, Justin P.
Burciu, Roxana G.
author_facet Bower, Abigail E.
Crisomia, Sophia J.
Chung, Jae Woo
Martello, Justin P.
Burciu, Roxana G.
author_sort Bower, Abigail E.
collection PubMed
description BACKGROUND: Research shows that individuals with Parkinson’s disease (PD) who have a postural instability and gait difficulties (PIGD) subtype have a faster disease progression compared to those with a tremor dominant (TD) subtype. Nevertheless, our understanding of the structural brain changes contributing to these clinical differences remains limited, primarily because many brain imaging techniques are only capable of detecting changes in the later stages of the disease. OBJECTIVE: Free water (FW) has emerged as a robust progression marker in several studies, showing increased values in the posterior substantia nigra that predict symptom worsening. Here, we examined longitudinal FW changes in TD and PIGD across multiple brain regions. METHODS: Participants were TD and PIGD enrolled in the Parkinson’s Progression Marker Initiative (PPMI) study who underwent diffusion MRI at baseline and 2 years later. FW changes were quantified for regions of interest (ROI) within the basal ganglia, thalamus, brainstem, and cerebellum. RESULTS: Baseline FW in all ROIs did not differ between groups. Over 2 years, PIGD had a greater percentage increase in FW in the putamen, globus pallidus, and cerebellar lobule V. A logistic regression model incorporating percent change in motor scores and FW in these brain regions achieved 91.4% accuracy in discriminating TD and PIGD, surpassing models based solely on clinical measures (74.3%) or imaging (76.1%). CONCLUSION: The results further suggest the use of FW to study disease progression in PD and provide insight into the differential course of brain changes in early-stage PD subtypes.
format Online
Article
Text
id pubmed-10642764
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-106427642023-11-14 Free water imaging unravels unique patterns of longitudinal structural brain changes in Parkinson’s disease subtypes Bower, Abigail E. Crisomia, Sophia J. Chung, Jae Woo Martello, Justin P. Burciu, Roxana G. Front Neurol Neurology BACKGROUND: Research shows that individuals with Parkinson’s disease (PD) who have a postural instability and gait difficulties (PIGD) subtype have a faster disease progression compared to those with a tremor dominant (TD) subtype. Nevertheless, our understanding of the structural brain changes contributing to these clinical differences remains limited, primarily because many brain imaging techniques are only capable of detecting changes in the later stages of the disease. OBJECTIVE: Free water (FW) has emerged as a robust progression marker in several studies, showing increased values in the posterior substantia nigra that predict symptom worsening. Here, we examined longitudinal FW changes in TD and PIGD across multiple brain regions. METHODS: Participants were TD and PIGD enrolled in the Parkinson’s Progression Marker Initiative (PPMI) study who underwent diffusion MRI at baseline and 2 years later. FW changes were quantified for regions of interest (ROI) within the basal ganglia, thalamus, brainstem, and cerebellum. RESULTS: Baseline FW in all ROIs did not differ between groups. Over 2 years, PIGD had a greater percentage increase in FW in the putamen, globus pallidus, and cerebellar lobule V. A logistic regression model incorporating percent change in motor scores and FW in these brain regions achieved 91.4% accuracy in discriminating TD and PIGD, surpassing models based solely on clinical measures (74.3%) or imaging (76.1%). CONCLUSION: The results further suggest the use of FW to study disease progression in PD and provide insight into the differential course of brain changes in early-stage PD subtypes. Frontiers Media S.A. 2023-10-30 /pmc/articles/PMC10642764/ /pubmed/37965163 http://dx.doi.org/10.3389/fneur.2023.1278065 Text en Copyright © 2023 Bower, Crisomia, Chung, Martello and Burciu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Bower, Abigail E.
Crisomia, Sophia J.
Chung, Jae Woo
Martello, Justin P.
Burciu, Roxana G.
Free water imaging unravels unique patterns of longitudinal structural brain changes in Parkinson’s disease subtypes
title Free water imaging unravels unique patterns of longitudinal structural brain changes in Parkinson’s disease subtypes
title_full Free water imaging unravels unique patterns of longitudinal structural brain changes in Parkinson’s disease subtypes
title_fullStr Free water imaging unravels unique patterns of longitudinal structural brain changes in Parkinson’s disease subtypes
title_full_unstemmed Free water imaging unravels unique patterns of longitudinal structural brain changes in Parkinson’s disease subtypes
title_short Free water imaging unravels unique patterns of longitudinal structural brain changes in Parkinson’s disease subtypes
title_sort free water imaging unravels unique patterns of longitudinal structural brain changes in parkinson’s disease subtypes
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642764/
https://www.ncbi.nlm.nih.gov/pubmed/37965163
http://dx.doi.org/10.3389/fneur.2023.1278065
work_keys_str_mv AT bowerabigaile freewaterimagingunravelsuniquepatternsoflongitudinalstructuralbrainchangesinparkinsonsdiseasesubtypes
AT crisomiasophiaj freewaterimagingunravelsuniquepatternsoflongitudinalstructuralbrainchangesinparkinsonsdiseasesubtypes
AT chungjaewoo freewaterimagingunravelsuniquepatternsoflongitudinalstructuralbrainchangesinparkinsonsdiseasesubtypes
AT martellojustinp freewaterimagingunravelsuniquepatternsoflongitudinalstructuralbrainchangesinparkinsonsdiseasesubtypes
AT burciuroxanag freewaterimagingunravelsuniquepatternsoflongitudinalstructuralbrainchangesinparkinsonsdiseasesubtypes