Cargando…

The short- and long-term readmission of four major categories of digestive system cancers: does obesity or metabolic disorder matter?

PURPOSE: Patients with digestive system cancers (DSCs) are at a high risk for hospitalizations; however, the risk factors for readmission remain unknown. Here, we established a retrospective cohort study to assess the association between metabolic obesity phenotypes and readmission risks of DSC. EXP...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yan, Wu, Xiaoqin, Song, Yongfeng, Wang, Peipei, Zhang, Bofei, Guo, Bingzhou, Liu, Ziwei, Wu, Yafei, Shao, Shanshan, Cheng, Yiping, Guo, Honglin, Fan, Xiude, Zhao, Jiajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642772/
https://www.ncbi.nlm.nih.gov/pubmed/37964973
http://dx.doi.org/10.3389/fendo.2023.1214651
_version_ 1785147019984109568
author Li, Yan
Wu, Xiaoqin
Song, Yongfeng
Wang, Peipei
Zhang, Bofei
Guo, Bingzhou
Liu, Ziwei
Wu, Yafei
Shao, Shanshan
Cheng, Yiping
Guo, Honglin
Fan, Xiude
Zhao, Jiajun
author_facet Li, Yan
Wu, Xiaoqin
Song, Yongfeng
Wang, Peipei
Zhang, Bofei
Guo, Bingzhou
Liu, Ziwei
Wu, Yafei
Shao, Shanshan
Cheng, Yiping
Guo, Honglin
Fan, Xiude
Zhao, Jiajun
author_sort Li, Yan
collection PubMed
description PURPOSE: Patients with digestive system cancers (DSCs) are at a high risk for hospitalizations; however, the risk factors for readmission remain unknown. Here, we established a retrospective cohort study to assess the association between metabolic obesity phenotypes and readmission risks of DSC. EXPERIMENTAL DESIGN: A total of 142,753 and 74,566 patients at index hospitalization were ultimately selected from the Nationwide Readmissions Database (NRD) 2018 to establish the 30-day and 180-day readmission cohorts, respectively. The study population was classified into four groups: metabolically healthy non-obese (MHNO), metabolically healthy obese (MHO), metabolically unhealthy non-obese (MUNO), and metabolically unhealthy obese (MUO). Multivariate Cox regression analysis was used to estimate the effect of metabolic obesity phenotypes on DSC readmission. RESULTS: The MUNO phenotype had 1.147-fold (95% CI: 1.066, 1.235; p < 0.001) increased 180-day readmission risks in patients with neoplasm of the upper digestive tract. The MUNO phenotype had 1.073-fold (95% CI: 1.027, 1.121; p = 0.002) increased 30-day readmission risks and 1.067-fold (95% CI: 1.021, 1.115; p = 0.004) increased 180-day readmission risks in patients with neoplasm of the lower digestive tract. The MUNO and MUO phenotypes were independent risk factors of readmission in patients with liver or pancreatic neoplasm. Metabolic obesity status was independently associated with a high risk of severe and unplanned hospitalization within 30 days or 180 days. CONCLUSION: Both obesity and metabolic abnormalities are associated with a high risk for the poor prognosis of DSC patients. The effect of metabolic categories on the short- or long-term readmission of liver or pancreas cancers may be stronger than that of obesity.
format Online
Article
Text
id pubmed-10642772
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-106427722023-11-14 The short- and long-term readmission of four major categories of digestive system cancers: does obesity or metabolic disorder matter? Li, Yan Wu, Xiaoqin Song, Yongfeng Wang, Peipei Zhang, Bofei Guo, Bingzhou Liu, Ziwei Wu, Yafei Shao, Shanshan Cheng, Yiping Guo, Honglin Fan, Xiude Zhao, Jiajun Front Endocrinol (Lausanne) Endocrinology PURPOSE: Patients with digestive system cancers (DSCs) are at a high risk for hospitalizations; however, the risk factors for readmission remain unknown. Here, we established a retrospective cohort study to assess the association between metabolic obesity phenotypes and readmission risks of DSC. EXPERIMENTAL DESIGN: A total of 142,753 and 74,566 patients at index hospitalization were ultimately selected from the Nationwide Readmissions Database (NRD) 2018 to establish the 30-day and 180-day readmission cohorts, respectively. The study population was classified into four groups: metabolically healthy non-obese (MHNO), metabolically healthy obese (MHO), metabolically unhealthy non-obese (MUNO), and metabolically unhealthy obese (MUO). Multivariate Cox regression analysis was used to estimate the effect of metabolic obesity phenotypes on DSC readmission. RESULTS: The MUNO phenotype had 1.147-fold (95% CI: 1.066, 1.235; p < 0.001) increased 180-day readmission risks in patients with neoplasm of the upper digestive tract. The MUNO phenotype had 1.073-fold (95% CI: 1.027, 1.121; p = 0.002) increased 30-day readmission risks and 1.067-fold (95% CI: 1.021, 1.115; p = 0.004) increased 180-day readmission risks in patients with neoplasm of the lower digestive tract. The MUNO and MUO phenotypes were independent risk factors of readmission in patients with liver or pancreatic neoplasm. Metabolic obesity status was independently associated with a high risk of severe and unplanned hospitalization within 30 days or 180 days. CONCLUSION: Both obesity and metabolic abnormalities are associated with a high risk for the poor prognosis of DSC patients. The effect of metabolic categories on the short- or long-term readmission of liver or pancreas cancers may be stronger than that of obesity. Frontiers Media S.A. 2023-10-30 /pmc/articles/PMC10642772/ /pubmed/37964973 http://dx.doi.org/10.3389/fendo.2023.1214651 Text en Copyright © 2023 Li, Wu, Song, Wang, Zhang, Guo, Liu, Wu, Shao, Cheng, Guo, Fan and Zhao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Li, Yan
Wu, Xiaoqin
Song, Yongfeng
Wang, Peipei
Zhang, Bofei
Guo, Bingzhou
Liu, Ziwei
Wu, Yafei
Shao, Shanshan
Cheng, Yiping
Guo, Honglin
Fan, Xiude
Zhao, Jiajun
The short- and long-term readmission of four major categories of digestive system cancers: does obesity or metabolic disorder matter?
title The short- and long-term readmission of four major categories of digestive system cancers: does obesity or metabolic disorder matter?
title_full The short- and long-term readmission of four major categories of digestive system cancers: does obesity or metabolic disorder matter?
title_fullStr The short- and long-term readmission of four major categories of digestive system cancers: does obesity or metabolic disorder matter?
title_full_unstemmed The short- and long-term readmission of four major categories of digestive system cancers: does obesity or metabolic disorder matter?
title_short The short- and long-term readmission of four major categories of digestive system cancers: does obesity or metabolic disorder matter?
title_sort short- and long-term readmission of four major categories of digestive system cancers: does obesity or metabolic disorder matter?
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642772/
https://www.ncbi.nlm.nih.gov/pubmed/37964973
http://dx.doi.org/10.3389/fendo.2023.1214651
work_keys_str_mv AT liyan theshortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT wuxiaoqin theshortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT songyongfeng theshortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT wangpeipei theshortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT zhangbofei theshortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT guobingzhou theshortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT liuziwei theshortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT wuyafei theshortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT shaoshanshan theshortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT chengyiping theshortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT guohonglin theshortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT fanxiude theshortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT zhaojiajun theshortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT liyan shortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT wuxiaoqin shortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT songyongfeng shortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT wangpeipei shortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT zhangbofei shortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT guobingzhou shortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT liuziwei shortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT wuyafei shortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT shaoshanshan shortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT chengyiping shortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT guohonglin shortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT fanxiude shortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter
AT zhaojiajun shortandlongtermreadmissionoffourmajorcategoriesofdigestivesystemcancersdoesobesityormetabolicdisordermatter