STING-driven activation of T cells: relevance for the adoptive cell therapy of cancer

Adoptive cell therapy (ACT) can successfully treat hematopoietic cancers but lacks efficacy against solid tumors. This is due to insufficient T cell infiltration, high tumor heterogeneity, frequent antigen loss with subsequent tumor escape, and the immunosuppressive tumor microenvironment (TME). Alt...

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Detalles Bibliográficos
Autores principales: Richter, Fabian, Paget, Christophe, Apetoh, Lionel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642958/
https://www.ncbi.nlm.nih.gov/pubmed/37970489
http://dx.doi.org/10.15698/cst2023.11.291

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