Smith–Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling

Retinoic acid-induced 1 (RAI1) haploinsufficiency causes Smith–Magenis syndrome (SMS), a genetic disorder with symptoms including hyperphagia, hyperlipidemia, severe obesity, and autism phenotypes. RAI1 is a transcriptional regulator with a pan-neural expression pattern and hundreds of downstream ta...

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Detalles Bibliográficos
Autores principales: Javed, Sehrish, Chang, Ya-Ting, Cho, Yoobin, Lee, Yu-Ju, Chang, Hao-Cheng, Haque, Minza, Lin, Yu Cheng, Huang, Wei-Hsiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642964/
https://www.ncbi.nlm.nih.gov/pubmed/37956053
http://dx.doi.org/10.7554/eLife.90333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642964/
https://www.ncbi.nlm.nih.gov/pubmed/37956053
http://dx.doi.org/10.7554/eLife.90333

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