A novel role for PGE(2)-EP(4) in the developmental programming of the mouse ductus arteriosus: consequences for vessel maturation and function

The ductus arteriosus (DA) is a vascular shunt that allows oxygenated blood to bypass the developing lungs in utero. Fetal DA patency requires vasodilatory signaling via the prostaglandin E(2) (PGE(2)) receptor EP(4). However, in humans and mice, disrupted PGE(2)-EP(4) signaling in utero causes unex...

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Detalles Bibliográficos
Autores principales: Yarboro, Michael T., Boatwright, Naoko, Sekulich, Deanna C., Hooper, Christopher W., Wong, Ting, Poole, Stanley D., Berger, Courtney D., Brown, Alexus J., Jetter, Christopher S., Sucre, Jennifer M. S., Shelton, Elaine L., Reese, Jeff
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643004/
https://www.ncbi.nlm.nih.gov/pubmed/37566109
http://dx.doi.org/10.1152/ajpheart.00294.2023

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