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Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney

Cisplatin (CDDP) is a commonly prescribed chemotherapeutic agent; however, its associated nephrotoxicity limits its clinical efficacy and sometimes requires discontinuation of its use. The existing study was designed to explore the reno-therapeutic efficacy of turmeric (Tur) alone or conjugated with...

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Autores principales: ALRashdi, Barakat M., Mohamed, Roaya A., Mohamed, Amal H., Samoul, Feryal A., Mohamed, Mazen I., Moussa, Mohsen M., Alrashidi, Saad M., Dawod, Bassel, Habotta, Ola A., Abdel Moneim, Ahmed E., Ramadan, Shimaa S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643052/
https://www.ncbi.nlm.nih.gov/pubmed/37902021
http://dx.doi.org/10.1042/BSR20231130
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author ALRashdi, Barakat M.
Mohamed, Roaya A.
Mohamed, Amal H.
Samoul, Feryal A.
Mohamed, Mazen I.
Moussa, Mohsen M.
Alrashidi, Saad M.
Dawod, Bassel
Habotta, Ola A.
Abdel Moneim, Ahmed E.
Ramadan, Shimaa S.
author_facet ALRashdi, Barakat M.
Mohamed, Roaya A.
Mohamed, Amal H.
Samoul, Feryal A.
Mohamed, Mazen I.
Moussa, Mohsen M.
Alrashidi, Saad M.
Dawod, Bassel
Habotta, Ola A.
Abdel Moneim, Ahmed E.
Ramadan, Shimaa S.
author_sort ALRashdi, Barakat M.
collection PubMed
description Cisplatin (CDDP) is a commonly prescribed chemotherapeutic agent; however, its associated nephrotoxicity limits its clinical efficacy and sometimes requires discontinuation of its use. The existing study was designed to explore the reno-therapeutic efficacy of turmeric (Tur) alone or conjugated with selenium nanoparticles (Tur-SeNPs) against CDDP-mediated renal impairment in mice and the mechanisms underlying this effect. Mice were orally treated with Tur extract (200 mg/kg) or Tur-SeNPs (0.5 mg/kg) for 7 days after administration of a single dose of CDDP (5 mg/kg, i.p.). N-acetyl cysteine NAC (100 mg/kg) was used as a standard antioxidant compound. The results revealed that Tur-SeNPs counteracted CDDP-mediated serious renal effects in treated mice. Compared with the controls, Tur or Tur-SeNPs therapy remarkably decreased the kidney index along with the serum levels of urea, creatinine, Kim-1, and NGAL of the CDDP-injected mice. Furthermore, Tur-SeNPs ameliorated the renal oxidant status of CDDP group demonstrated by decreased MDA and NO levels along with elevated levels of SOD, CAT, GPx, GR, GSH, and gene expression levels of HO-1. Noteworthy, lessening of renal inflammation was exerted by Tur-SeNPs via lessening of IL-6 and TNF-α besides down-regulation of NF-κB gene expression in mouse kidneys. Tur-SeNPs treatment also restored the renal histological features attained by CDDP challenge and hindered renal apoptosis through decreasing the Bax levels and increasing Bcl-2 levels. Altogether, these outcomes suggest that the administration of Tur conjugated with SeNPs is effective neoadjuvant chemotherapy to guard against the renal adverse effects that are associated with CDDP therapy.
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spelling pubmed-106430522023-11-15 Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney ALRashdi, Barakat M. Mohamed, Roaya A. Mohamed, Amal H. Samoul, Feryal A. Mohamed, Mazen I. Moussa, Mohsen M. Alrashidi, Saad M. Dawod, Bassel Habotta, Ola A. Abdel Moneim, Ahmed E. Ramadan, Shimaa S. Biosci Rep Therapeutics & Molecular Medicine Cisplatin (CDDP) is a commonly prescribed chemotherapeutic agent; however, its associated nephrotoxicity limits its clinical efficacy and sometimes requires discontinuation of its use. The existing study was designed to explore the reno-therapeutic efficacy of turmeric (Tur) alone or conjugated with selenium nanoparticles (Tur-SeNPs) against CDDP-mediated renal impairment in mice and the mechanisms underlying this effect. Mice were orally treated with Tur extract (200 mg/kg) or Tur-SeNPs (0.5 mg/kg) for 7 days after administration of a single dose of CDDP (5 mg/kg, i.p.). N-acetyl cysteine NAC (100 mg/kg) was used as a standard antioxidant compound. The results revealed that Tur-SeNPs counteracted CDDP-mediated serious renal effects in treated mice. Compared with the controls, Tur or Tur-SeNPs therapy remarkably decreased the kidney index along with the serum levels of urea, creatinine, Kim-1, and NGAL of the CDDP-injected mice. Furthermore, Tur-SeNPs ameliorated the renal oxidant status of CDDP group demonstrated by decreased MDA and NO levels along with elevated levels of SOD, CAT, GPx, GR, GSH, and gene expression levels of HO-1. Noteworthy, lessening of renal inflammation was exerted by Tur-SeNPs via lessening of IL-6 and TNF-α besides down-regulation of NF-κB gene expression in mouse kidneys. Tur-SeNPs treatment also restored the renal histological features attained by CDDP challenge and hindered renal apoptosis through decreasing the Bax levels and increasing Bcl-2 levels. Altogether, these outcomes suggest that the administration of Tur conjugated with SeNPs is effective neoadjuvant chemotherapy to guard against the renal adverse effects that are associated with CDDP therapy. Portland Press Ltd. 2023-11-10 /pmc/articles/PMC10643052/ /pubmed/37902021 http://dx.doi.org/10.1042/BSR20231130 Text en © 2023 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Therapeutics & Molecular Medicine
ALRashdi, Barakat M.
Mohamed, Roaya A.
Mohamed, Amal H.
Samoul, Feryal A.
Mohamed, Mazen I.
Moussa, Mohsen M.
Alrashidi, Saad M.
Dawod, Bassel
Habotta, Ola A.
Abdel Moneim, Ahmed E.
Ramadan, Shimaa S.
Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney
title Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney
title_full Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney
title_fullStr Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney
title_full_unstemmed Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney
title_short Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney
title_sort therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney
topic Therapeutics & Molecular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643052/
https://www.ncbi.nlm.nih.gov/pubmed/37902021
http://dx.doi.org/10.1042/BSR20231130
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