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The Notch signaling-regulated angiogenesis in rheumatoid arthritis: pathogenic mechanisms and therapeutic potentials

Angiogenesis plays a key role in the pathological process of inflammation and invasion of the synovium, and primarily drives the progression of rheumatoid arthritis (RA). Recent studies have demonstrated that the Notch signaling may represent a new therapeutic target of RA. Although the Notch signal...

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Autores principales: Zhao, Fang, He, Yini, Zhao, Zhihao, He, Jiarong, Huang, Hong, Ai, Kelong, Liu, Liang, Cai, Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643158/
https://www.ncbi.nlm.nih.gov/pubmed/38022508
http://dx.doi.org/10.3389/fimmu.2023.1272133
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author Zhao, Fang
He, Yini
Zhao, Zhihao
He, Jiarong
Huang, Hong
Ai, Kelong
Liu, Liang
Cai, Xiong
author_facet Zhao, Fang
He, Yini
Zhao, Zhihao
He, Jiarong
Huang, Hong
Ai, Kelong
Liu, Liang
Cai, Xiong
author_sort Zhao, Fang
collection PubMed
description Angiogenesis plays a key role in the pathological process of inflammation and invasion of the synovium, and primarily drives the progression of rheumatoid arthritis (RA). Recent studies have demonstrated that the Notch signaling may represent a new therapeutic target of RA. Although the Notch signaling has been implicated in the M1 polarization of macrophages and the differentiation of lymphocytes, little is known about its role in angiogenesis in RA. In this review, we discourse the unique roles of stromal cells and adipokines in the angiogenic progression of RA, and investigate how epigenetic regulation of the Notch signaling influences angiogenesis in RA. We also discuss the interaction of the Notch-HIF signaling in RA’s angiogenesis and the potential strategies targeting the Notch signaling to improve the treatment outcomes of RA. Taken together, we further suggest new insights into future research regarding the challenges in the therapeutic strategies of RA.
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spelling pubmed-106431582023-01-01 The Notch signaling-regulated angiogenesis in rheumatoid arthritis: pathogenic mechanisms and therapeutic potentials Zhao, Fang He, Yini Zhao, Zhihao He, Jiarong Huang, Hong Ai, Kelong Liu, Liang Cai, Xiong Front Immunol Immunology Angiogenesis plays a key role in the pathological process of inflammation and invasion of the synovium, and primarily drives the progression of rheumatoid arthritis (RA). Recent studies have demonstrated that the Notch signaling may represent a new therapeutic target of RA. Although the Notch signaling has been implicated in the M1 polarization of macrophages and the differentiation of lymphocytes, little is known about its role in angiogenesis in RA. In this review, we discourse the unique roles of stromal cells and adipokines in the angiogenic progression of RA, and investigate how epigenetic regulation of the Notch signaling influences angiogenesis in RA. We also discuss the interaction of the Notch-HIF signaling in RA’s angiogenesis and the potential strategies targeting the Notch signaling to improve the treatment outcomes of RA. Taken together, we further suggest new insights into future research regarding the challenges in the therapeutic strategies of RA. Frontiers Media S.A. 2023-10-26 /pmc/articles/PMC10643158/ /pubmed/38022508 http://dx.doi.org/10.3389/fimmu.2023.1272133 Text en Copyright © 2023 Zhao, He, Zhao, He, Huang, Ai, Liu and Cai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhao, Fang
He, Yini
Zhao, Zhihao
He, Jiarong
Huang, Hong
Ai, Kelong
Liu, Liang
Cai, Xiong
The Notch signaling-regulated angiogenesis in rheumatoid arthritis: pathogenic mechanisms and therapeutic potentials
title The Notch signaling-regulated angiogenesis in rheumatoid arthritis: pathogenic mechanisms and therapeutic potentials
title_full The Notch signaling-regulated angiogenesis in rheumatoid arthritis: pathogenic mechanisms and therapeutic potentials
title_fullStr The Notch signaling-regulated angiogenesis in rheumatoid arthritis: pathogenic mechanisms and therapeutic potentials
title_full_unstemmed The Notch signaling-regulated angiogenesis in rheumatoid arthritis: pathogenic mechanisms and therapeutic potentials
title_short The Notch signaling-regulated angiogenesis in rheumatoid arthritis: pathogenic mechanisms and therapeutic potentials
title_sort notch signaling-regulated angiogenesis in rheumatoid arthritis: pathogenic mechanisms and therapeutic potentials
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643158/
https://www.ncbi.nlm.nih.gov/pubmed/38022508
http://dx.doi.org/10.3389/fimmu.2023.1272133
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