Cargando…

Active tuberculosis patients have high systemic IgG levels and B-cell fingerprinting, characterized by a reduced capacity to produce IFN-γ or IL-10 as a response to M.tb antigens

INTRODUCTION: Tuberculosis (TB) is a bacterial infection caused by Mycobacterium tuberculosis (M.tb). B cells are the central mediator of the humoral response; they are responsible for producing antibodies in addition to mediating other functions. The role of the cellular response during the TB spec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Flores-Gonzalez, Julio, Urbán-Solano, Alexia, Ramón-Luing, Lucero A., Cancino-Diaz, Juan Carlos, Contreras-Rodriguez, Araceli, Curiel-Quesada, Everardo, Hernández-Pando, Rogelio, Chavez-Galan, Leslie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643169/ https://www.ncbi.nlm.nih.gov/pubmed/38022616 http://dx.doi.org/10.3389/fimmu.2023.1263458

Ejemplares similares

Latent Tuberculosis Patients Have an Increased Frequency of IFN-γ-Producing CD5+ B Cells, Which Respond Efficiently to Mycobacterial Proteins
por: Flores-Gonzalez, Julio, et al.
Publicado: (2023)

High levels of PF4, VEGF-A, and classical monocytes correlate with the platelets count and inflammation during active tuberculosis
por: Urbán-Solano, Alexia, et al.
Publicado: (2022)

Anti-tuberculosis chemotherapy alters TNFR2 expression on CD4+ lymphocytes in both drug-sensitive and -resistant tuberculosis: however, only drug-resistant tuberculosis maintains a pro-inflammatory profile after a long time
por: Téllez-Navarrete, Norma A., et al.
Publicado: (2021)

Pre-Exposure of Mycobacterium tuberculosis-Infected Macrophages to Crystalline Silica Impairs Control of Bacterial Growth by Deregulating the Balance between Apoptosis and Necrosis
por: Chávez-Galán, Leslie, et al.
Publicado: (2013)

Hierarchy Low CD4+/CD8+ T-Cell Counts and IFN-γ Responses in HIV-1+ Individuals Correlate with Active TB and/or M.tb Co-Infection
por: Shao, Lingyun, et al.
Publicado: (2016)

Discrepancy between Mtb-specific IFN-γ and IgG responses in HIV-positive people with low CD4 counts
por: Mthembu, Maphe, et al.
Publicado: (2023)

Diagnostic performance of GeneXpert MTB/RIF in detecting MTB in smear-negative presumptive TB patients
por: Rimal, Raksha, et al.
Publicado: (2022)

Lipoarabinomannan Decreases Galectin-9 Expression and Tumor Necrosis Factor Pathway in Macrophages Favoring Mycobacterium tuberculosis Intracellular Growth
por: Chávez-Galán, Leslie, et al.
Publicado: (2017)

Contribution of Xpert(®) MTB/RIF to pediatric TB diagnosis in Mozambique
por: Mutemba, C. M., et al.
Publicado: (2023)

Cytokine response to selected MTB antigens in Ghanaian TB patients, before and at 2 weeks of anti-TB therapy is characterized by high expression of IFN-γ and Granzyme B and inter- individual variation
por: Mensah, Gloria Ivy, et al.
Publicado: (2014)

Virulence Factors of Mycobacterium tuberculosis as Modulators of Cell Death Mechanisms
por: Ramon-Luing, Lucero A., et al.
Publicado: (2023)

Impact of valganciclovir therapy on severe IRIS-Kaposi Sarcoma mortality: An open-label, parallel, randomized controlled trial
por: Volkow, Patricia, et al.
Publicado: (2023)

Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children
por: Comella-del-Barrio, Patricia, et al.
Publicado: (2021)

TNF/IFN-GAMMA AXIS FAVORS SENESCENCE AND SEVERE INFLAMMATION ASSOCIATED WITH CELL DEATH IN PATIENTS WITH COVID-19
por: PALACIOS, Y., et al.
Publicado: (2022)

Impact of introduction of Xpert MTB/RIF test on tuberculosis (TB) diagnosis in a city with high TB incidence in Brazil
por: Pereira, Giovana Rodrigues, et al.
Publicado: (2018)

System-wide identification of myeloid markers of TB disease and HIV-induced reactivation in the macaque model of Mtb infection and Mtb/SIV co-infection
por: Gough, Maya, et al.
Publicado: (2022)

Murine RAW Macrophages Are a Suitable Model to Study the CD3 Signaling in Myeloid Cells
por: Ocaña-Guzmán, Ranferi, et al.
Publicado: (2022)

Diagnosis of paediatric TB using Xpert(®) MTB/RIF Ultra on fresh respiratory samples
por: Sabi, I., et al.
Publicado: (2022)

Use of Xpert MTB/RIF in Decentralized Public Health Settings and Its Effect on Pulmonary TB and DR-TB Case Finding in India
por: Sachdeva, Kuldeep Singh, et al.
Publicado: (2015)

Piloting Upfront Xpert MTB/RIF Testing on Various Specimens under Programmatic Conditions for Diagnosis of TB & DR-TB in Paediatric Population
por: Raizada, Neeraj, et al.
Publicado: (2015)

The effect of sputum quality and volume on the yield of bacteriologically-confirmed TB by Xpert MTB/RIF and smear
por: Zimba, Onani, et al.
Publicado: (2019)

New TB Tools Need to be Affordable in the Private Sector: The Case Study of Xpert MTB/RIF
por: Ponnudurai, Nirros, et al.
Publicado: (2018)

Upfront Xpert MTB/RIF for diagnosis of pediatric TB—Does it work? Experience from India
por: Kalra, Aakshi, et al.
Publicado: (2020)

Mycobacterium tuberculosis H37Rv Strain Increases the Frequency of CD3(+)TCR(+) Macrophages and Affects Their Phenotype, but Not Their Migration Ability
por: Ramon-Luing, Lucero A., et al.
Publicado: (2021)

Enhancing TB Case Detection: Experience in Offering Upfront Xpert MTB/RIF Testing to Pediatric Presumptive TB and DR TB Cases for Early Rapid Diagnosis of Drug Sensitive and Drug Resistant TB
por: Raizada, Neeraj, et al.
Publicado: (2014)

A pre-clinical validation plan to evaluate analytical sensitivities of molecular diagnostics such as BD MAX MDR-TB, Xpert MTB/Rif Ultra and FluoroType MTB
por: Beutler, Markus, et al.
Publicado: (2020)

Diagnostic Performance of Xpert MTB/RIF Ultra Compared with Predecessor Test, Xpert MTB/RIF, in a Low TB Incidence Setting: a Retrospective Service Evaluation
por: Mansfield, Mary, et al.
Publicado: (2022)

Impact of GeneXpert MTB/RIF® on treatment initiation and outcomes of RIF-resistant and RIF-susceptible TB patients in Vladimir TB dispensary, Russia
por: Ershova, Julia V., et al.
Publicado: (2020)

A Class 4-like Chromosomal Integron Found in Aeromonas sp. Genomospecies paramedia Isolated from Human Feces
por: Baltazar-Cruz, Jesús, et al.
Publicado: (2023)

Immune Phenotype and Functionality of Mtb-Specific T-Cells in HIV/TB Co-Infected Patients on Antiretroviral Treatment
por: Mupfumi, Lucy, et al.
Publicado: (2020)

Role of Xpert MTB/RIF in Bronchoalveolar lavage fluid of sputum-scarce, suspected Pulmonary TB patients
por: Kilaru, Satish Chandra, et al.
Publicado: (2018)

Comparative Analysis on Proteomics Profiles of Intracellular and Extracellular M.tb and BCG From Infected Human Macrophages
por: Liu, Han, et al.
Publicado: (2022)

Evaluation of trace calls by Xpert MTB/RIF ultra for clinical management in low TB burden settings
por: Amedeo, Alberto, et al.
Publicado: (2022)

Catching the Missing Million: Experiences in Enhancing TB & DR-TB Detection by Providing Upfront Xpert MTB/RIF Testing for People Living with HIV in India
por: Raizada, Neeraj, et al.
Publicado: (2015)

Phase I Trial Evaluating the Safety and Immunogenicity of Candidate TB Vaccine MVA85A, Delivered by Aerosol to Healthy M.tb-Infected Adults
por: Riste, Michael, et al.
Publicado: (2021)

Detection of Mycobacterium tuberculosis in clinical sputum by a unique gene in MTB strains called Conserved protein TB18.5 (TB18.5)
por: Luo, Juanxiu, et al.
Publicado: (2021)

Valganciclovir as Add-On Therapy Modifies the Frequency of NK and NKT Cell Subpopulations in Disseminated Kaposi Sarcoma Patients
por: Flores-Gonzalez, Julio, et al.
Publicado: (2022)

Bacterial Loads Measured by the Xpert MTB/RIF Assay as Markers of Culture Conversion and Bacteriological Cure in Pulmonary TB
por: Shenai, Shubhada, et al.
Publicado: (2016)

Mycobacterium tuberculosis thymidylate kinase antigen assays for designating incipient, high-risk latent M.tb infection
por: Wayengera, Misaki, et al.
Publicado: (2018)

Hepcidin deficiency and iron deficiency do not alter tuberculosis susceptibility in a murine M.tb infection model
por: Harrington-Kandt, Rachel, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_p7tlhv68h1jancpuf5fk4hmk10