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Expanding structural diversity of 5′-aminouridine moiety of sansanmycin via mutational biosynthesis

Sansanmycins represent a family of uridyl peptide antibiotics with antimicrobial activity specifically against Mycobacterium tuberculosis (including drug-resistant M. tuberculosis) and Pseudomonas aeruginosa. They target translocase I (MraY) to inhibit bacterial cell wall assembly. Given the unique...

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Detalles Bibliográficos
Autores principales:	Lu, Yuan, Li, Yihong, Fan, Jiahui, Li, Xingxing, Sun, Hongmin, Wang, Lifei, Han, Xingli, Zhu, Yuting, Zhang, Tianyu, Shi, Yuanyuan, Xie, Yunying, Hong, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643210/ https://www.ncbi.nlm.nih.gov/pubmed/38026887 http://dx.doi.org/10.3389/fbioe.2023.1278601

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