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Targeting mitochondrial shape: at the heart of cardioprotection

There remains an unmet need to identify novel therapeutic strategies capable of protecting the myocardium against the detrimental effects of acute ischemia–reperfusion injury (IRI), to reduce myocardial infarct (MI) size and prevent the onset of heart failure (HF) following acute myocardial infarcti...

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Autores principales: Hernandez-Resendiz, Sauri, Prakash, Aishwarya, Loo, Sze Jie, Semenzato, Martina, Chinda, Kroekkiat, Crespo-Avilan, Gustavo E., Dam, Linh Chi, Lu, Shengjie, Scorrano, Luca, Hausenloy, Derek J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643419/
https://www.ncbi.nlm.nih.gov/pubmed/37955687
http://dx.doi.org/10.1007/s00395-023-01019-9
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author Hernandez-Resendiz, Sauri
Prakash, Aishwarya
Loo, Sze Jie
Semenzato, Martina
Chinda, Kroekkiat
Crespo-Avilan, Gustavo E.
Dam, Linh Chi
Lu, Shengjie
Scorrano, Luca
Hausenloy, Derek J.
author_facet Hernandez-Resendiz, Sauri
Prakash, Aishwarya
Loo, Sze Jie
Semenzato, Martina
Chinda, Kroekkiat
Crespo-Avilan, Gustavo E.
Dam, Linh Chi
Lu, Shengjie
Scorrano, Luca
Hausenloy, Derek J.
author_sort Hernandez-Resendiz, Sauri
collection PubMed
description There remains an unmet need to identify novel therapeutic strategies capable of protecting the myocardium against the detrimental effects of acute ischemia–reperfusion injury (IRI), to reduce myocardial infarct (MI) size and prevent the onset of heart failure (HF) following acute myocardial infarction (AMI). In this regard, perturbations in mitochondrial morphology with an imbalance in mitochondrial fusion and fission can disrupt mitochondrial metabolism, calcium homeostasis, and reactive oxygen species production, factors which are all known to be critical determinants of cardiomyocyte death following acute myocardial IRI. As such, therapeutic approaches directed at preserving the morphology and functionality of mitochondria may provide an important strategy for cardioprotection. In this article, we provide an overview of the alterations in mitochondrial morphology which occur in response to acute myocardial IRI, and highlight the emerging therapeutic strategies for targeting mitochondrial shape to preserve mitochondrial function which have the future therapeutic potential to improve health outcomes in patients presenting with AMI.
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spelling pubmed-106434192023-11-14 Targeting mitochondrial shape: at the heart of cardioprotection Hernandez-Resendiz, Sauri Prakash, Aishwarya Loo, Sze Jie Semenzato, Martina Chinda, Kroekkiat Crespo-Avilan, Gustavo E. Dam, Linh Chi Lu, Shengjie Scorrano, Luca Hausenloy, Derek J. Basic Res Cardiol Mitochondria at the Heart of Cardioprotection There remains an unmet need to identify novel therapeutic strategies capable of protecting the myocardium against the detrimental effects of acute ischemia–reperfusion injury (IRI), to reduce myocardial infarct (MI) size and prevent the onset of heart failure (HF) following acute myocardial infarction (AMI). In this regard, perturbations in mitochondrial morphology with an imbalance in mitochondrial fusion and fission can disrupt mitochondrial metabolism, calcium homeostasis, and reactive oxygen species production, factors which are all known to be critical determinants of cardiomyocyte death following acute myocardial IRI. As such, therapeutic approaches directed at preserving the morphology and functionality of mitochondria may provide an important strategy for cardioprotection. In this article, we provide an overview of the alterations in mitochondrial morphology which occur in response to acute myocardial IRI, and highlight the emerging therapeutic strategies for targeting mitochondrial shape to preserve mitochondrial function which have the future therapeutic potential to improve health outcomes in patients presenting with AMI. Springer Berlin Heidelberg 2023-11-13 2023 /pmc/articles/PMC10643419/ /pubmed/37955687 http://dx.doi.org/10.1007/s00395-023-01019-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mitochondria at the Heart of Cardioprotection
Hernandez-Resendiz, Sauri
Prakash, Aishwarya
Loo, Sze Jie
Semenzato, Martina
Chinda, Kroekkiat
Crespo-Avilan, Gustavo E.
Dam, Linh Chi
Lu, Shengjie
Scorrano, Luca
Hausenloy, Derek J.
Targeting mitochondrial shape: at the heart of cardioprotection
title Targeting mitochondrial shape: at the heart of cardioprotection
title_full Targeting mitochondrial shape: at the heart of cardioprotection
title_fullStr Targeting mitochondrial shape: at the heart of cardioprotection
title_full_unstemmed Targeting mitochondrial shape: at the heart of cardioprotection
title_short Targeting mitochondrial shape: at the heart of cardioprotection
title_sort targeting mitochondrial shape: at the heart of cardioprotection
topic Mitochondria at the Heart of Cardioprotection
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643419/
https://www.ncbi.nlm.nih.gov/pubmed/37955687
http://dx.doi.org/10.1007/s00395-023-01019-9
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