Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson’s disease mouse model

Mutations in SNCA, the gene encoding α-synuclein (αSyn), cause familial Parkinson’s disease (PD) and aberrant αSyn is a key pathological hallmark of idiopathic PD. This α-synucleinopathy leads to mitochondrial dysfunction, which may drive dopaminergic neurodegeneration. PARKIN and PINK1, mutated in...

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Detalles Bibliográficos
Autores principales: Fang, Tracy-Shi Zhang, Sun, Yu, Pearce, Andrew C., Eleuteri, Simona, Kemp, Mark, Luckhurst, Christopher A., Williams, Rachel, Mills, Ross, Almond, Sarah, Burzynski, Laura, Márkus, Nóra M., Lelliott, Christopher J., Karp, Natasha A., Adams, David J., Jackson, Stephen P., Zhao, Jin-Feng, Ganley, Ian G., Thompson, Paul W., Balmus, Gabriel, Simon, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643470/
https://www.ncbi.nlm.nih.gov/pubmed/37957154
http://dx.doi.org/10.1038/s41467-023-42876-1

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