Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review

Coronavirus Disease 2019 (COVID-19) is known to have various, neurological manifestations. We herein report three patients with MRI-negative myelitis following COVID-19 with abnormal somatosensory evoked potentials (SEPs). Decreased amplitude of the cortical potential and prolonged latency in the SE...

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Autores principales: Kawama, Kentaro, Shimazaki, Rui, Sunami, Yoko, Miyakoshi, Natsuki, Tobisawa, Shinsuke, Shimizu, Toshio, Takahashi, Kazushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643519/
https://www.ncbi.nlm.nih.gov/pubmed/38020593
http://dx.doi.org/10.3389/fneur.2023.1275696
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author Kawama, Kentaro
Shimazaki, Rui
Sunami, Yoko
Miyakoshi, Natsuki
Tobisawa, Shinsuke
Shimizu, Toshio
Takahashi, Kazushi
author_facet Kawama, Kentaro
Shimazaki, Rui
Sunami, Yoko
Miyakoshi, Natsuki
Tobisawa, Shinsuke
Shimizu, Toshio
Takahashi, Kazushi
author_sort Kawama, Kentaro
collection PubMed
description Coronavirus Disease 2019 (COVID-19) is known to have various, neurological manifestations. We herein report three patients with MRI-negative myelitis following COVID-19 with abnormal somatosensory evoked potentials (SEPs). Decreased amplitude of the cortical potential and prolonged latency in the SEPs contributed to diagnosing myelitis in the present patients. The SEP findings improved as the neurological symptoms improved. Despite a delay in initiating immunosuppressive treatment after myelitis onset, all the patients improved clinically. In the light of recent progress in COVID-19 research, several hypotheses can be made to explain the pathophysiology underlying MRI-negative myelitis, including antibody-binding and microglial synapse elimination.
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spelling pubmed-106435192023-10-19 Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review Kawama, Kentaro Shimazaki, Rui Sunami, Yoko Miyakoshi, Natsuki Tobisawa, Shinsuke Shimizu, Toshio Takahashi, Kazushi Front Neurol Neurology Coronavirus Disease 2019 (COVID-19) is known to have various, neurological manifestations. We herein report three patients with MRI-negative myelitis following COVID-19 with abnormal somatosensory evoked potentials (SEPs). Decreased amplitude of the cortical potential and prolonged latency in the SEPs contributed to diagnosing myelitis in the present patients. The SEP findings improved as the neurological symptoms improved. Despite a delay in initiating immunosuppressive treatment after myelitis onset, all the patients improved clinically. In the light of recent progress in COVID-19 research, several hypotheses can be made to explain the pathophysiology underlying MRI-negative myelitis, including antibody-binding and microglial synapse elimination. Frontiers Media S.A. 2023-10-19 /pmc/articles/PMC10643519/ /pubmed/38020593 http://dx.doi.org/10.3389/fneur.2023.1275696 Text en Copyright © 2023 Kawama, Shimazaki, Sunami, Miyakoshi, Tobisawa, Shimizu and Takahashi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Kawama, Kentaro
Shimazaki, Rui
Sunami, Yoko
Miyakoshi, Natsuki
Tobisawa, Shinsuke
Shimizu, Toshio
Takahashi, Kazushi
Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review
title Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review
title_full Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review
title_fullStr Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review
title_full_unstemmed Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review
title_short Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review
title_sort case report: mri-negative myelitis following covid-19 with sep abnormalities: a case series and literature review
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643519/
https://www.ncbi.nlm.nih.gov/pubmed/38020593
http://dx.doi.org/10.3389/fneur.2023.1275696
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