Reactivity-based RNA profiling for analyzing transcriptome interactions of small molecules in human cells

Protein-targeted small-molecule drugs may unintentionally bind intracellular RNA, contributing to drug toxicity. Moreover, new drugs are actively sought for intentionally targeting RNA. Here, we present a protocol to globally profile RNA-drug interactions in human cells using acylating probes and ne...

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Detalles Bibliográficos
Autores principales: Fang, Linglan, Kool, Eric T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643522/
https://www.ncbi.nlm.nih.gov/pubmed/37917579
http://dx.doi.org/10.1016/j.xpro.2023.102670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643522/
https://www.ncbi.nlm.nih.gov/pubmed/37917579
http://dx.doi.org/10.1016/j.xpro.2023.102670

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