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Reactivity-based RNA profiling for analyzing transcriptome interactions of small molecules in human cells
Protein-targeted small-molecule drugs may unintentionally bind intracellular RNA, contributing to drug toxicity. Moreover, new drugs are actively sought for intentionally targeting RNA. Here, we present a protocol to globally profile RNA-drug interactions in human cells using acylating probes and ne...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643522/ https://www.ncbi.nlm.nih.gov/pubmed/37917579 http://dx.doi.org/10.1016/j.xpro.2023.102670 |