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Frequency of respiratory virus-associated infection among children and adolescents from a tertiary-care hospital in Mexico City
Acute respiratory infections (ARIs) are a major cause of morbidity and mortality among children. The causative pathogens show geographic and seasonal variations. We retrospectively evaluated the frequency and seasonality of respiratory pathogens in children and adolescents (age: 0–19 years) with ARI...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643542/ https://www.ncbi.nlm.nih.gov/pubmed/37957308 http://dx.doi.org/10.1038/s41598-023-47035-6 |
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author | Nieto-Rivera, Brenda Saldaña-Ahuactzi, Zeus Parra-Ortega, Israel Flores-Alanis, Alejandro Carbajal-Franco, Ebzadrel Cruz-Rangel, Armando Galaviz-Hernández, Stephania Romero-Navarro, Benjamín de la Rosa-Zamboni, Daniela Salazar-García, Marcela Contreras, Carmen A. Ortega-Riosvelasco, Fernando López-Martínez, Irma Barrera-Badillo, Gisela Diaz-Garcia, Hector Romo-Castillo, Mariana Moreno-Espinosa, Sarbelio Luna-Pineda, Victor M. |
author_facet | Nieto-Rivera, Brenda Saldaña-Ahuactzi, Zeus Parra-Ortega, Israel Flores-Alanis, Alejandro Carbajal-Franco, Ebzadrel Cruz-Rangel, Armando Galaviz-Hernández, Stephania Romero-Navarro, Benjamín de la Rosa-Zamboni, Daniela Salazar-García, Marcela Contreras, Carmen A. Ortega-Riosvelasco, Fernando López-Martínez, Irma Barrera-Badillo, Gisela Diaz-Garcia, Hector Romo-Castillo, Mariana Moreno-Espinosa, Sarbelio Luna-Pineda, Victor M. |
author_sort | Nieto-Rivera, Brenda |
collection | PubMed |
description | Acute respiratory infections (ARIs) are a major cause of morbidity and mortality among children. The causative pathogens show geographic and seasonal variations. We retrospectively evaluated the frequency and seasonality of respiratory pathogens in children and adolescents (age: 0–19 years) with ARIs treated between January 1, 2021, and March 31, 2022, at a single center in Mexico. Out of 2400 patients, 1,603 were diagnosed with SARS-CoV-2 infection and 797 were diagnosed with other common respiratory pathogens (CRPs). Of the 797 patients, 632 were infected with one CRP and 165 with > 2 CRPs. Deaths occurred only in SARS-CoV-2-infected patients. Rhinovirus/Enterovirus, respiratory syncytial virus B, and parainfluenza virus 3 were the most prevalent in cases with single and multiple infections. CRP showed a high frequency between autumn and winter of 2021, with higher incidence of hospitalization compared to COVID-19. The main comorbidities were immunosuppression, cardiovascular disease (CD), and asthma. The frequency of CRPs showed a downward trend throughout the first half of 2021. CRPs increased in single- and co-infection cases between the fourth and fifth waves of COVID-19, probably due to decreased nonpharmaceutical interventions and changes in diagnostic tests. Age, cyanosis (symptom), and immunosuppression (comorbidity) were found to differentiate between SARS-CoV-2 infection and CRP infection. |
format | Online Article Text |
id | pubmed-10643542 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-106435422023-11-13 Frequency of respiratory virus-associated infection among children and adolescents from a tertiary-care hospital in Mexico City Nieto-Rivera, Brenda Saldaña-Ahuactzi, Zeus Parra-Ortega, Israel Flores-Alanis, Alejandro Carbajal-Franco, Ebzadrel Cruz-Rangel, Armando Galaviz-Hernández, Stephania Romero-Navarro, Benjamín de la Rosa-Zamboni, Daniela Salazar-García, Marcela Contreras, Carmen A. Ortega-Riosvelasco, Fernando López-Martínez, Irma Barrera-Badillo, Gisela Diaz-Garcia, Hector Romo-Castillo, Mariana Moreno-Espinosa, Sarbelio Luna-Pineda, Victor M. Sci Rep Article Acute respiratory infections (ARIs) are a major cause of morbidity and mortality among children. The causative pathogens show geographic and seasonal variations. We retrospectively evaluated the frequency and seasonality of respiratory pathogens in children and adolescents (age: 0–19 years) with ARIs treated between January 1, 2021, and March 31, 2022, at a single center in Mexico. Out of 2400 patients, 1,603 were diagnosed with SARS-CoV-2 infection and 797 were diagnosed with other common respiratory pathogens (CRPs). Of the 797 patients, 632 were infected with one CRP and 165 with > 2 CRPs. Deaths occurred only in SARS-CoV-2-infected patients. Rhinovirus/Enterovirus, respiratory syncytial virus B, and parainfluenza virus 3 were the most prevalent in cases with single and multiple infections. CRP showed a high frequency between autumn and winter of 2021, with higher incidence of hospitalization compared to COVID-19. The main comorbidities were immunosuppression, cardiovascular disease (CD), and asthma. The frequency of CRPs showed a downward trend throughout the first half of 2021. CRPs increased in single- and co-infection cases between the fourth and fifth waves of COVID-19, probably due to decreased nonpharmaceutical interventions and changes in diagnostic tests. Age, cyanosis (symptom), and immunosuppression (comorbidity) were found to differentiate between SARS-CoV-2 infection and CRP infection. Nature Publishing Group UK 2023-11-13 /pmc/articles/PMC10643542/ /pubmed/37957308 http://dx.doi.org/10.1038/s41598-023-47035-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Nieto-Rivera, Brenda Saldaña-Ahuactzi, Zeus Parra-Ortega, Israel Flores-Alanis, Alejandro Carbajal-Franco, Ebzadrel Cruz-Rangel, Armando Galaviz-Hernández, Stephania Romero-Navarro, Benjamín de la Rosa-Zamboni, Daniela Salazar-García, Marcela Contreras, Carmen A. Ortega-Riosvelasco, Fernando López-Martínez, Irma Barrera-Badillo, Gisela Diaz-Garcia, Hector Romo-Castillo, Mariana Moreno-Espinosa, Sarbelio Luna-Pineda, Victor M. Frequency of respiratory virus-associated infection among children and adolescents from a tertiary-care hospital in Mexico City |
title | Frequency of respiratory virus-associated infection among children and adolescents from a tertiary-care hospital in Mexico City |
title_full | Frequency of respiratory virus-associated infection among children and adolescents from a tertiary-care hospital in Mexico City |
title_fullStr | Frequency of respiratory virus-associated infection among children and adolescents from a tertiary-care hospital in Mexico City |
title_full_unstemmed | Frequency of respiratory virus-associated infection among children and adolescents from a tertiary-care hospital in Mexico City |
title_short | Frequency of respiratory virus-associated infection among children and adolescents from a tertiary-care hospital in Mexico City |
title_sort | frequency of respiratory virus-associated infection among children and adolescents from a tertiary-care hospital in mexico city |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643542/ https://www.ncbi.nlm.nih.gov/pubmed/37957308 http://dx.doi.org/10.1038/s41598-023-47035-6 |
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