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The prognostic role of gastrointestinal bleeding in patients with a primary gastrointestinal stromal tumor: a long-term follow-up study

BACKGROUND: Gastrointestinal (GI) bleeding is one of the common symptoms of GI stromal tumor (GIST). Although several studies have highlighted its prognostic role, conclusions have been inconsistent. This study aimed to investigate the prognosis of GIST patients with GI bleeding. METHODS: Primary GI...

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Autores principales: Shi, Xiaoxiao, Chen, Zhou, Shou, Chunhui, Bai, Hao, Yang, Weili, Zhang, Qing, Liu, Xiaosun, Yu, Jiren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643578/
https://www.ncbi.nlm.nih.gov/pubmed/37969844
http://dx.doi.org/10.21037/jgo-22-1240
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author Shi, Xiaoxiao
Chen, Zhou
Shou, Chunhui
Bai, Hao
Yang, Weili
Zhang, Qing
Liu, Xiaosun
Yu, Jiren
author_facet Shi, Xiaoxiao
Chen, Zhou
Shou, Chunhui
Bai, Hao
Yang, Weili
Zhang, Qing
Liu, Xiaosun
Yu, Jiren
author_sort Shi, Xiaoxiao
collection PubMed
description BACKGROUND: Gastrointestinal (GI) bleeding is one of the common symptoms of GI stromal tumor (GIST). Although several studies have highlighted its prognostic role, conclusions have been inconsistent. This study aimed to investigate the prognosis of GIST patients with GI bleeding. METHODS: Primary GIST patients who underwent complete resection and did not receive adjuvant imatinib therapy from January 2003 to December 2008 were reviewed. The Kaplan-Meier method was used to estimate recurrence-free survival (RFS), and multivariate analysis was performed using the Cox proportional hazard model. Propensity score matching (PSM) was conducted to reduce confounders. A systematic review of the published articles in the PubMed, Embase, Cochrane Collaboration, and Medline databases was also conducted, and the inclusion criteria were determined using PICOS (patients, intervention, comparison, outcomes, and study design) principles. RESULTS: In total, 84 patients presenting with GI bleeding and 90 patients without GI bleeding were enrolled in this study. The median time of follow-up was 140 months (range, 10–196 months), and 38 patients developed tumor recurrence/metastasis. For all patients, the multivariate analysis indicated that tumor location [hazard ratio (HR) =3.48, 95% confidence interval (CI): 1.78–6.82, P<0.001], tumor size (HR =1.91, 95% CI: 1.05–3.47, P=0.035), mitotic index (MI; HR =5.69, 95% CI: 2.77–11.67, P<0.001), and age (HR =2.68, 95% CI: 1.49–4.82, P=0.001) were the independent prognostic factors for poor RFS. However, GI bleeding was not associated with RFS (HR =1.21, 95% CI: 0.68–2.14, P=0.518). After PSM, 45 patients from each group were included, and it was found that GI bleeding was still not the independent prognostic factor (HR =1.23, 95% CI: 0.51–2.97, P=0.642). Moreover, the pooled results of our study and six previously reported studies showed that GI bleeding was not the independent prognostic factor (HR =1.45, 95% CI: 0.73–2.86, P=0.287). CONCLUSIONS: In this study, tumor location, tumor size, MI, and age were independent prognostic factors in primary GIST patients who underwent radical resection. However, GI bleeding was not associated with worse RFS.
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spelling pubmed-106435782023-11-15 The prognostic role of gastrointestinal bleeding in patients with a primary gastrointestinal stromal tumor: a long-term follow-up study Shi, Xiaoxiao Chen, Zhou Shou, Chunhui Bai, Hao Yang, Weili Zhang, Qing Liu, Xiaosun Yu, Jiren J Gastrointest Oncol Original Article BACKGROUND: Gastrointestinal (GI) bleeding is one of the common symptoms of GI stromal tumor (GIST). Although several studies have highlighted its prognostic role, conclusions have been inconsistent. This study aimed to investigate the prognosis of GIST patients with GI bleeding. METHODS: Primary GIST patients who underwent complete resection and did not receive adjuvant imatinib therapy from January 2003 to December 2008 were reviewed. The Kaplan-Meier method was used to estimate recurrence-free survival (RFS), and multivariate analysis was performed using the Cox proportional hazard model. Propensity score matching (PSM) was conducted to reduce confounders. A systematic review of the published articles in the PubMed, Embase, Cochrane Collaboration, and Medline databases was also conducted, and the inclusion criteria were determined using PICOS (patients, intervention, comparison, outcomes, and study design) principles. RESULTS: In total, 84 patients presenting with GI bleeding and 90 patients without GI bleeding were enrolled in this study. The median time of follow-up was 140 months (range, 10–196 months), and 38 patients developed tumor recurrence/metastasis. For all patients, the multivariate analysis indicated that tumor location [hazard ratio (HR) =3.48, 95% confidence interval (CI): 1.78–6.82, P<0.001], tumor size (HR =1.91, 95% CI: 1.05–3.47, P=0.035), mitotic index (MI; HR =5.69, 95% CI: 2.77–11.67, P<0.001), and age (HR =2.68, 95% CI: 1.49–4.82, P=0.001) were the independent prognostic factors for poor RFS. However, GI bleeding was not associated with RFS (HR =1.21, 95% CI: 0.68–2.14, P=0.518). After PSM, 45 patients from each group were included, and it was found that GI bleeding was still not the independent prognostic factor (HR =1.23, 95% CI: 0.51–2.97, P=0.642). Moreover, the pooled results of our study and six previously reported studies showed that GI bleeding was not the independent prognostic factor (HR =1.45, 95% CI: 0.73–2.86, P=0.287). CONCLUSIONS: In this study, tumor location, tumor size, MI, and age were independent prognostic factors in primary GIST patients who underwent radical resection. However, GI bleeding was not associated with worse RFS. AME Publishing Company 2023-09-11 2023-10-31 /pmc/articles/PMC10643578/ /pubmed/37969844 http://dx.doi.org/10.21037/jgo-22-1240 Text en 2023 Journal of Gastrointestinal Oncology. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Shi, Xiaoxiao
Chen, Zhou
Shou, Chunhui
Bai, Hao
Yang, Weili
Zhang, Qing
Liu, Xiaosun
Yu, Jiren
The prognostic role of gastrointestinal bleeding in patients with a primary gastrointestinal stromal tumor: a long-term follow-up study
title The prognostic role of gastrointestinal bleeding in patients with a primary gastrointestinal stromal tumor: a long-term follow-up study
title_full The prognostic role of gastrointestinal bleeding in patients with a primary gastrointestinal stromal tumor: a long-term follow-up study
title_fullStr The prognostic role of gastrointestinal bleeding in patients with a primary gastrointestinal stromal tumor: a long-term follow-up study
title_full_unstemmed The prognostic role of gastrointestinal bleeding in patients with a primary gastrointestinal stromal tumor: a long-term follow-up study
title_short The prognostic role of gastrointestinal bleeding in patients with a primary gastrointestinal stromal tumor: a long-term follow-up study
title_sort prognostic role of gastrointestinal bleeding in patients with a primary gastrointestinal stromal tumor: a long-term follow-up study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643578/
https://www.ncbi.nlm.nih.gov/pubmed/37969844
http://dx.doi.org/10.21037/jgo-22-1240
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