A CRISPR-drug perturbational map for identifying compounds to combine with commonly used chemotherapeutics

Combination chemotherapy is crucial for successfully treating cancer. However, the enormous number of possible drug combinations means discovering safe and effective combinations remains a significant challenge. To improve this process, we conduct large-scale targeted CRISPR knockout screens in drug...

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Detalles Bibliográficos
Autores principales: Lee, Hyeong-Min, Wright, William C., Pan, Min, Low, Jonathan, Currier, Duane, Fang, Jie, Singh, Shivendra, Nance, Stephanie, Delahunty, Ian, Kim, Yuna, Chapple, Richard H., Zhang, Yinwen, Liu, Xueying, Steele, Jacob A., Qi, Jun, Pruett-Miller, Shondra M., Easton, John, Chen, Taosheng, Yang, Jun, Durbin, Adam D., Geeleher, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643606/
https://www.ncbi.nlm.nih.gov/pubmed/37957169
http://dx.doi.org/10.1038/s41467-023-43134-0

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