The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT)

Aging muscle experiences functional decline in part mediated by impaired mitochondrial ADP sensitivity. Elamipretide (ELAM) rapidly improves physiological and mitochondrial function in aging and binds directly to the mitochondrial ADP transporter ANT. We hypothesized that ELAM improves ADP sensitivi...

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Detalles Bibliográficos
Autores principales: Pharaoh, Gavin, Kamat, Varun, Kannan, Sricharan, Stuppard, Rudolph S., Whitson, Jeremy, Martín-Pérez, Miguel, Qian, Wei-Jun, MacCoss, Michael J., Villén, Judit, Rabinovitch, Peter, Campbell, Matthew D., Sweet, Ian R., Marcinek, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643647/
https://www.ncbi.nlm.nih.gov/pubmed/37462785
http://dx.doi.org/10.1007/s11357-023-00861-y

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