Vascular senescence and leak are features of the early breakdown of the blood–brain barrier in Alzheimer’s disease models

Alzheimer’s disease (AD) is an age-related disease, with loss of integrity of the blood–brain barrier (BBB) being an early feature. Cellular senescence is one of the reported nine hallmarks of aging. Here, we show for the first time the presence of senescent cells in the vasculature in AD patients a...

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Detalles Bibliográficos
Autores principales: Ting, Ka Ka, Coleman, Paul, Kim, Hani Jieun, Zhao, Yang, Mulangala, Jocelyne, Cheng, Ngan Ching, Li, Wan, Gunatilake, Dilini, Johnstone, Daniel M., Loo, Lipin, Neely, G. Gregory, Yang, Pengyi, Götz, Jürgen, Vadas, Mathew A., Gamble, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643714/
https://www.ncbi.nlm.nih.gov/pubmed/37782439
http://dx.doi.org/10.1007/s11357-023-00927-x

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