Relevance and consequence of chronic inflammation for obesity development

BACKGROUND: Increasing prevalence of morbid obesity accompanied by comorbidities like type 2 diabetes mellitus (T2DM) led to a demand for improving therapeutic strategies and pharmacological intervention options. Apart from genetics, inflammation processes have been hypothesized to be of importance...

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Detalles Bibliográficos
Autores principales: Ruck, Lisa, Wiegand, Susanna, Kühnen, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643747/
https://www.ncbi.nlm.nih.gov/pubmed/37957462
http://dx.doi.org/10.1186/s40348-023-00170-6
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author Ruck, Lisa
Wiegand, Susanna
Kühnen, Peter
author_facet Ruck, Lisa
Wiegand, Susanna
Kühnen, Peter
author_sort Ruck, Lisa
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description BACKGROUND: Increasing prevalence of morbid obesity accompanied by comorbidities like type 2 diabetes mellitus (T2DM) led to a demand for improving therapeutic strategies and pharmacological intervention options. Apart from genetics, inflammation processes have been hypothesized to be of importance for the development of obesity and related aspects like insulin resistance. MAIN TEXT: Within this review, we provide an overview of the intricate interplay between chronic inflammation of the adipose tissue and the hypothalamus and the development of obesity. Further understanding of this relationship might improve the understanding of the underlying mechanism and may be of relevance for the establishment of new treatment strategies.
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spelling pubmed-106437472023-11-14 Relevance and consequence of chronic inflammation for obesity development Ruck, Lisa Wiegand, Susanna Kühnen, Peter Mol Cell Pediatr Review BACKGROUND: Increasing prevalence of morbid obesity accompanied by comorbidities like type 2 diabetes mellitus (T2DM) led to a demand for improving therapeutic strategies and pharmacological intervention options. Apart from genetics, inflammation processes have been hypothesized to be of importance for the development of obesity and related aspects like insulin resistance. MAIN TEXT: Within this review, we provide an overview of the intricate interplay between chronic inflammation of the adipose tissue and the hypothalamus and the development of obesity. Further understanding of this relationship might improve the understanding of the underlying mechanism and may be of relevance for the establishment of new treatment strategies. Springer International Publishing 2023-11-14 /pmc/articles/PMC10643747/ /pubmed/37957462 http://dx.doi.org/10.1186/s40348-023-00170-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Ruck, Lisa
Wiegand, Susanna
Kühnen, Peter
Relevance and consequence of chronic inflammation for obesity development
title Relevance and consequence of chronic inflammation for obesity development
title_full Relevance and consequence of chronic inflammation for obesity development
title_fullStr Relevance and consequence of chronic inflammation for obesity development
title_full_unstemmed Relevance and consequence of chronic inflammation for obesity development
title_short Relevance and consequence of chronic inflammation for obesity development
title_sort relevance and consequence of chronic inflammation for obesity development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643747/
https://www.ncbi.nlm.nih.gov/pubmed/37957462
http://dx.doi.org/10.1186/s40348-023-00170-6
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