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Altered functional connectivity of the nucleus tractus solitarii in patients with chronic cough after lung surgery: an rs‐fMRI study

BACKGROUND: To explore the altered functional connectivity (FC) of the nucleus tractus solitarii (NTS) in patients with chronic cough after lung surgery using resting‐state functional magnetic resonance imaging (rs‐fMRI), and the association between abnormal FC and clinical scale scores. METHODS: A...

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Autores principales: Wu, Ming‐sheng, Chen, Zheng‐wei, Chen, Xiao, Wang, Gao‐xiang, Xu, Chun‐sheng, Zhu, Yong‐fu, Xie, Ming‐ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643787/
https://www.ncbi.nlm.nih.gov/pubmed/37718475
http://dx.doi.org/10.1111/1759-7714.15110
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author Wu, Ming‐sheng
Chen, Zheng‐wei
Chen, Xiao
Wang, Gao‐xiang
Xu, Chun‐sheng
Zhu, Yong‐fu
Xie, Ming‐ran
author_facet Wu, Ming‐sheng
Chen, Zheng‐wei
Chen, Xiao
Wang, Gao‐xiang
Xu, Chun‐sheng
Zhu, Yong‐fu
Xie, Ming‐ran
author_sort Wu, Ming‐sheng
collection PubMed
description BACKGROUND: To explore the altered functional connectivity (FC) of the nucleus tractus solitarii (NTS) in patients with chronic cough after lung surgery using resting‐state functional magnetic resonance imaging (rs‐fMRI), and the association between abnormal FC and clinical scale scores. METHODS: A total of 22 patients with chronic cough after lung surgery and 22 healthy controls were included. Visual analog scale (VAS), Mandarin Chinese version of the Leicester Cough Questionnaire (LCQ‐MC), and Hamilton anxiety rating scale (HAMA) scores were assessed, and rs‐fMRI data were collected. The FC analysis was performed using the NTS as the seed point, and FC values with all voxels in the whole brain were calculated. A two‐sample t‐test was used to compare FC differences between the two groups. The FC values of brain regions with differences were extracted and correlated with clinical scale scores. RESULTS: In comparison to healthy controls, FC values in the NTS and anterior cingulate cortex(ACC) were reduced in patients with chronic cough after lung surgery (GRF correction, p‐voxel < 0.005, p‐cluster < 0.05) which were positively correlated with LCQ‐MC scores (r = 0.534, p = 0.011), but with VAS (r = −0.500, p = 0.018), HAMA (r = −0.713, p < 0.001) scores were negatively correlated. CONCLUSIONS: Reduced FC of the NTS with ACC may be associated with cough hypersensitivity and may contribute to anxiety in patients with chronic cough after lung surgery.
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spelling pubmed-106437872023-11-15 Altered functional connectivity of the nucleus tractus solitarii in patients with chronic cough after lung surgery: an rs‐fMRI study Wu, Ming‐sheng Chen, Zheng‐wei Chen, Xiao Wang, Gao‐xiang Xu, Chun‐sheng Zhu, Yong‐fu Xie, Ming‐ran Thorac Cancer Original Articles BACKGROUND: To explore the altered functional connectivity (FC) of the nucleus tractus solitarii (NTS) in patients with chronic cough after lung surgery using resting‐state functional magnetic resonance imaging (rs‐fMRI), and the association between abnormal FC and clinical scale scores. METHODS: A total of 22 patients with chronic cough after lung surgery and 22 healthy controls were included. Visual analog scale (VAS), Mandarin Chinese version of the Leicester Cough Questionnaire (LCQ‐MC), and Hamilton anxiety rating scale (HAMA) scores were assessed, and rs‐fMRI data were collected. The FC analysis was performed using the NTS as the seed point, and FC values with all voxels in the whole brain were calculated. A two‐sample t‐test was used to compare FC differences between the two groups. The FC values of brain regions with differences were extracted and correlated with clinical scale scores. RESULTS: In comparison to healthy controls, FC values in the NTS and anterior cingulate cortex(ACC) were reduced in patients with chronic cough after lung surgery (GRF correction, p‐voxel < 0.005, p‐cluster < 0.05) which were positively correlated with LCQ‐MC scores (r = 0.534, p = 0.011), but with VAS (r = −0.500, p = 0.018), HAMA (r = −0.713, p < 0.001) scores were negatively correlated. CONCLUSIONS: Reduced FC of the NTS with ACC may be associated with cough hypersensitivity and may contribute to anxiety in patients with chronic cough after lung surgery. John Wiley & Sons Australia, Ltd 2023-09-17 /pmc/articles/PMC10643787/ /pubmed/37718475 http://dx.doi.org/10.1111/1759-7714.15110 Text en © 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Wu, Ming‐sheng
Chen, Zheng‐wei
Chen, Xiao
Wang, Gao‐xiang
Xu, Chun‐sheng
Zhu, Yong‐fu
Xie, Ming‐ran
Altered functional connectivity of the nucleus tractus solitarii in patients with chronic cough after lung surgery: an rs‐fMRI study
title Altered functional connectivity of the nucleus tractus solitarii in patients with chronic cough after lung surgery: an rs‐fMRI study
title_full Altered functional connectivity of the nucleus tractus solitarii in patients with chronic cough after lung surgery: an rs‐fMRI study
title_fullStr Altered functional connectivity of the nucleus tractus solitarii in patients with chronic cough after lung surgery: an rs‐fMRI study
title_full_unstemmed Altered functional connectivity of the nucleus tractus solitarii in patients with chronic cough after lung surgery: an rs‐fMRI study
title_short Altered functional connectivity of the nucleus tractus solitarii in patients with chronic cough after lung surgery: an rs‐fMRI study
title_sort altered functional connectivity of the nucleus tractus solitarii in patients with chronic cough after lung surgery: an rs‐fmri study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643787/
https://www.ncbi.nlm.nih.gov/pubmed/37718475
http://dx.doi.org/10.1111/1759-7714.15110
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