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The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment

Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB) that remains a significant global health challenge. The extensive use of antibiotics in tuberculosis treatment, disrupts the delicate balance of the microbiota in various organs, including the gastrointestinal an...

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Autores principales: Alvarado-Peña, Néstor, Galeana-Cadena, David, Gómez-García, Itzel Alejandra, Mainero, Xavier Soberón, Silva-Herzog, Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643882/
https://www.ncbi.nlm.nih.gov/pubmed/38029121
http://dx.doi.org/10.3389/fmicb.2023.1237998
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author Alvarado-Peña, Néstor
Galeana-Cadena, David
Gómez-García, Itzel Alejandra
Mainero, Xavier Soberón
Silva-Herzog, Eugenia
author_facet Alvarado-Peña, Néstor
Galeana-Cadena, David
Gómez-García, Itzel Alejandra
Mainero, Xavier Soberón
Silva-Herzog, Eugenia
author_sort Alvarado-Peña, Néstor
collection PubMed
description Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB) that remains a significant global health challenge. The extensive use of antibiotics in tuberculosis treatment, disrupts the delicate balance of the microbiota in various organs, including the gastrointestinal and respiratory systems. This gut-lung axis involves dynamic interactions among immune cells, microbiota, and signaling molecules from both organs. The alterations of the microbiome resulting from anti-TB treatment can significantly influence the course of tuberculosis, impacting aspects such as complete healing, reinfection, and relapse. This review aims to provide a comprehensive understanding of the gut-lung axis in the context of tuberculosis, with a specific focus on the impact of anti-TB treatment on the microbiome.
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spelling pubmed-106438822023-10-31 The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment Alvarado-Peña, Néstor Galeana-Cadena, David Gómez-García, Itzel Alejandra Mainero, Xavier Soberón Silva-Herzog, Eugenia Front Microbiol Microbiology Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB) that remains a significant global health challenge. The extensive use of antibiotics in tuberculosis treatment, disrupts the delicate balance of the microbiota in various organs, including the gastrointestinal and respiratory systems. This gut-lung axis involves dynamic interactions among immune cells, microbiota, and signaling molecules from both organs. The alterations of the microbiome resulting from anti-TB treatment can significantly influence the course of tuberculosis, impacting aspects such as complete healing, reinfection, and relapse. This review aims to provide a comprehensive understanding of the gut-lung axis in the context of tuberculosis, with a specific focus on the impact of anti-TB treatment on the microbiome. Frontiers Media S.A. 2023-10-31 /pmc/articles/PMC10643882/ /pubmed/38029121 http://dx.doi.org/10.3389/fmicb.2023.1237998 Text en Copyright © 2023 Alvarado-Peña, Galeana-Cadena, Gómez-García, Mainero and Silva-Herzog. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Alvarado-Peña, Néstor
Galeana-Cadena, David
Gómez-García, Itzel Alejandra
Mainero, Xavier Soberón
Silva-Herzog, Eugenia
The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment
title The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment
title_full The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment
title_fullStr The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment
title_full_unstemmed The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment
title_short The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment
title_sort microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643882/
https://www.ncbi.nlm.nih.gov/pubmed/38029121
http://dx.doi.org/10.3389/fmicb.2023.1237998
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