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The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment
Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB) that remains a significant global health challenge. The extensive use of antibiotics in tuberculosis treatment, disrupts the delicate balance of the microbiota in various organs, including the gastrointestinal an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643882/ https://www.ncbi.nlm.nih.gov/pubmed/38029121 http://dx.doi.org/10.3389/fmicb.2023.1237998 |
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author | Alvarado-Peña, Néstor Galeana-Cadena, David Gómez-García, Itzel Alejandra Mainero, Xavier Soberón Silva-Herzog, Eugenia |
author_facet | Alvarado-Peña, Néstor Galeana-Cadena, David Gómez-García, Itzel Alejandra Mainero, Xavier Soberón Silva-Herzog, Eugenia |
author_sort | Alvarado-Peña, Néstor |
collection | PubMed |
description | Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB) that remains a significant global health challenge. The extensive use of antibiotics in tuberculosis treatment, disrupts the delicate balance of the microbiota in various organs, including the gastrointestinal and respiratory systems. This gut-lung axis involves dynamic interactions among immune cells, microbiota, and signaling molecules from both organs. The alterations of the microbiome resulting from anti-TB treatment can significantly influence the course of tuberculosis, impacting aspects such as complete healing, reinfection, and relapse. This review aims to provide a comprehensive understanding of the gut-lung axis in the context of tuberculosis, with a specific focus on the impact of anti-TB treatment on the microbiome. |
format | Online Article Text |
id | pubmed-10643882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106438822023-10-31 The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment Alvarado-Peña, Néstor Galeana-Cadena, David Gómez-García, Itzel Alejandra Mainero, Xavier Soberón Silva-Herzog, Eugenia Front Microbiol Microbiology Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB) that remains a significant global health challenge. The extensive use of antibiotics in tuberculosis treatment, disrupts the delicate balance of the microbiota in various organs, including the gastrointestinal and respiratory systems. This gut-lung axis involves dynamic interactions among immune cells, microbiota, and signaling molecules from both organs. The alterations of the microbiome resulting from anti-TB treatment can significantly influence the course of tuberculosis, impacting aspects such as complete healing, reinfection, and relapse. This review aims to provide a comprehensive understanding of the gut-lung axis in the context of tuberculosis, with a specific focus on the impact of anti-TB treatment on the microbiome. Frontiers Media S.A. 2023-10-31 /pmc/articles/PMC10643882/ /pubmed/38029121 http://dx.doi.org/10.3389/fmicb.2023.1237998 Text en Copyright © 2023 Alvarado-Peña, Galeana-Cadena, Gómez-García, Mainero and Silva-Herzog. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Alvarado-Peña, Néstor Galeana-Cadena, David Gómez-García, Itzel Alejandra Mainero, Xavier Soberón Silva-Herzog, Eugenia The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment |
title | The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment |
title_full | The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment |
title_fullStr | The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment |
title_full_unstemmed | The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment |
title_short | The microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment |
title_sort | microbiome and the gut-lung axis in tuberculosis: interplay in the course of disease and treatment |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643882/ https://www.ncbi.nlm.nih.gov/pubmed/38029121 http://dx.doi.org/10.3389/fmicb.2023.1237998 |
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