Cargando…

Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19

Mannose-binding lectin-associated serine protease 2 (MASP-2) is the main activator of the lectin complement pathway and has been suggested to be involved in the pathophysiology of coronavirus disease 2019 (COVID-19). To study a possible association between MASP-2 and COVID-19, we aimed at developing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Götz, Maximilian Peter, Skjoedt, Mikkel-Ole, Bayarri-Olmos, Rafael, Hansen, Cecilie Bo, Pérez-Alós, Laura, Jarlhelt, Ida, Benfield, Thomas, Rosbjerg, Anne, Garred, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	S. Karger AG 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643890/ https://www.ncbi.nlm.nih.gov/pubmed/35816998 http://dx.doi.org/10.1159/000525508

Ejemplares similares

SARS-CoV-2 Antibodies Mediate Complement and Cellular Driven Inflammation
por: Jarlhelt, Ida, et al.
Publicado: (2021)

Complementary Roles of the Classical and Lectin Complement Pathways in the Defense against Aspergillus fumigatus
por: Rosbjerg, Anne, et al.
Publicado: (2016)

Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody
por: Cyranka, Leon, et al.
Publicado: (2023)

Chimeric Proteins Containing MAP-1 and Functional Domains of C4b-Binding Protein Reveal Strong Complement Inhibitory Capacities
por: Hertz, Cecilie E., et al.
Publicado: (2018)

The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization
por: Bayarri-Olmos, Rafael, et al.
Publicado: (2021)

Reply to Lassaunière: On the functional characterization of the Y453F RBD variant found in cluster 5 SARS-CoV-2
por: Bayarri-Olmos, Rafael, et al.
Publicado: (2021)

Development of a Quantitative Assay for the Characterization of Human Collectin-11 (CL-11, CL-K1)
por: Bayarri-Olmos, Rafael, et al.
Publicado: (2018)

Evasion Mechanisms Used by Pathogens to Escape the Lectin Complement Pathway
por: Rosbjerg, Anne, et al.
Publicado: (2017)

The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice
por: Bayarri-Olmos, Rafael, et al.
Publicado: (2021)

Functional Effects of Receptor-Binding Domain Mutations of SARS-CoV-2 B.1.351 and P.1 Variants
por: Bayarri-Olmos, Rafael, et al.
Publicado: (2021)

Interactions between mannose-binding lectin and MASPs during complement activation by the lectin pathway
por: Wallis, Russell
Publicado: (2007)

The Lectin Complement Pathway Is Involved in Protection Against Enteroaggregative Escherichia coli Infection
por: Adler Sørensen, Camilla, et al.
Publicado: (2018)

The complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway retains MASP-3 in the circulation
por: Kusakari, Kohei, et al.
Publicado: (2022)

Mannan-binding lectin serine protease-2 (MASP-2) in human kidney and its relevance for proteolytic activation of the epithelial sodium channel
por: Zachar, Rikke, et al.
Publicado: (2022)

C-Reactive Protein Binds to Cholesterol Crystals and Co-Localizes with the Terminal Complement Complex in Human Atherosclerotic Plaques
por: Pilely, Katrine, et al.
Publicado: (2017)

Functional Analysis of Ficolin-3 Mediated Complement Activation
por: Hein, Estrid, et al.
Publicado: (2010)

Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria
por: Holmberg, Ville, et al.
Publicado: (2012)

Cleavage of Kininogen and Subsequent Bradykinin Release by the Complement Component: Mannose-Binding Lectin-Associated Serine Protease (MASP)-1
por: Dobó, József, et al.
Publicado: (2011)

MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked
por: Dobó, József, et al.
Publicado: (2016)

Pentraxin 3, ficolin-2 and lectin pathway associated serine protease MASP-3 as early predictors of myocardial infarction - the HUNT2 study
por: Vengen, Inga Thorsen, et al.
Publicado: (2017)

Mutations in the lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome
por: Rooryck, Caroline, et al.
Publicado: (2011)

Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation
por: Gao, Ting, et al.
Publicado: (2022)

Complement lectin pathway components MBL and MASP-1 promote haemostasis upon vessel injury in a microvascular bleeding model
por: Golomingi, Murielle, et al.
Publicado: (2022)

Distinguishing SARS-CoV-2 infection and vaccine responses up to 18 months post-infection using nucleocapsid protein and receptor-binding domain antibodies
por: Jarlhelt, Ida, et al.
Publicado: (2023)

Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides
por: Dürvanger, Zsolt, et al.
Publicado: (2022)

Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpins
por: De Marco Verissimo, Carolina, et al.
Publicado: (2022)

Increase in the Complement Activation Product C4d and the Terminal Complement Complex sC5b-9 Is Associated with Disease Severity and a Fatal Outcome in Necrotizing Soft-Tissue Infection
por: Hedetoft, Morten, et al.
Publicado: (2021)

Targeted deletions of complement lectin pathway genes improve outcome in traumatic brain injury, with MASP-2 playing a major role
por: Mercurio, D., et al.
Publicado: (2020)

Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1
por: Orsini, Franca, et al.
Publicado: (2016)

Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation
por: Nagy, Zoltán Attila, et al.
Publicado: (2022)

Complement-Mediated Neutralization of Dengue Virus Requires Mannose-Binding Lectin
por: Avirutnan, Panisadee, et al.
Publicado: (2011)

Lectin complement pathway initiators after subarachnoid hemorrhage — an observational study
por: Matzen, Jeppe Sillesen, et al.
Publicado: (2020)

C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independent in vivo
por: Ruseva, M M, et al.
Publicado: (2014)

MASP-1 Induced Clotting – The First Model of Prothrombin Activation by MASP-1
por: Jenny, Lorenz, et al.
Publicado: (2015)

Effects of MASP-1 of the Complement System on Activation of Coagulation Factors and Plasma Clot Formation
por: Hess, Katharina, et al.
Publicado: (2012)

Cooperation of Complement MASP-1 with Other Proinflammatory Factors to Enhance the Activation of Endothelial Cells
por: Németh, Zsuzsanna, et al.
Publicado: (2023)

Should MASP-2 Deficiency Be Considered a Primary Immunodeficiency? Relevance of the Lectin Pathway
por: García-Laorden, M. Isabel, et al.
Publicado: (2019)

MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19
por: Bumiller-Bini, Valéria, et al.
Publicado: (2021)

Modeling of waning immunity after SARS-CoV-2 vaccination and influencing factors
por: Pérez-Alós, Laura, et al.
Publicado: (2022)

Polymorphisms in the MASP1 Gene Are Associated with Serum Levels of MASP-1, MASP-3, and MAp44
por: Gytz Ammitzbøll, Christian, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ntjmrhk1n185kjub2qbe2rb7ig