IRF1 Is Required for MDA5 (IFIH1) Induction by IFN-α, LPS, and poly(I:C) in Murine Macrophages

Melanoma differentiation-associated protein 5 (MDA5) induces type I interferons (IFNs) after the recognition of viral RNA. In addition, gain-of-function mutations in the interferon induced with helicase C domain 1 (IFIH1) gene, which encodes MDA5, lead to type I interferonopathies. Here, we show tha...

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Detalles Bibliográficos
Autores principales: Aparici-Herraiz, Iris, Sánchez-Sánchez, Guillem, Batlle, Carlos, Rehues, Pere, López-Serrat, Martí, Valverde-Estrella, Lorena, Lloberas, Jorge, Celada, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643899/
https://www.ncbi.nlm.nih.gov/pubmed/36380629
http://dx.doi.org/10.1159/000527008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643899/
https://www.ncbi.nlm.nih.gov/pubmed/36380629
http://dx.doi.org/10.1159/000527008

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